| Project/Area Number |
23657096
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biophysics
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| Research Institution | Hokkaido University |
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Principal Investigator |
DEMURA Makoto 北海道大学, 大学院・先端生命科学研究院, 教授 (70188704)
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| Project Period (FY) |
2012 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ハロロドプシン / オプトジェネティクス / 光遺伝学 / 膜タンパク質 / 光生物学 / 神経回路 / バイオコンピューター / ロドプシン / 神経 / 光吸収 |
|---|
| Research Abstract |
Human eye has a light-sensitive membrane protein. This sensor protein called rhodopsin that can identify the color of the light. Contrary, a rhodopsin-like proteins were found in some microorganisms, which have a light-driven ion transport (membrane potential) features different from the eyes. In this study, in order to improve the light-driven ion transport of microbial rhodopsin, the modified rhodopsins were prepared and visible absorption spectra in equilibrium and transient states, and the trimeric structure of modified rhodopsins were investigated.
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