| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Bed rest confined condition, so called in Japanese “Netakiri” has been an important social issue in Japan. It is difficult that “Netakiri” people return to an independent lifestyle. Then we thought to look for food stuff to accelerate recovery from “Netakiri” condition. T o do these experiments, we have established confined rat model which is similar to “Netakiri” human. “Netakiri” rat model showed hypercholesterolemia and liver injury. The secretion rate of VLDL-cholesterol from liver was increased in “Natakiri” rats as compared to controls. The increased secretion of VLDL would explain the hypercholesterolemia. DNA microarray analysis indicated that genes related to cell cycles and apoptosis are changed. These result might explain the liver injury. Gene expression related to sulfur-containing amino acid metabolism was also changed. This change led to abnormal cholesterol or bile acid metabolism. The changed cholesterol and bile acid metabolism would lead hypercholesterolemia. Dietary egg white protein suppressed the hypercholesterolemia induced by “Netakiri” condition. And soy protein isolate suppressed both hypercholesterolemia and liver injury. These indicate that some dietary factors can ameliorate metabolic abnormality and liver injury induce by “Netakiri” condition.
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