Molecular regulation of epigenetics of the cytochrome P450 genes by food chemicals
| Project/Area Number |
23658116
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Food science
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | P450 / エピジェネティック / がん / 食品毒性 / エピジェネティクス |
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| Research Abstract |
It is known that P450 which is a useful biological catalyst can carry out the monooxigenation of the medicine and chemicals.Especially P450 can carry out metabolic activation of various chemical substances which participate in the generation of cancer cells. We know that the chemical substance with has mutagenicity can increase the cancer cells in our body. In general, these mutagenic chemicals are metabolic activated by P450 monooxygenase. On the other hand, there is a little information about the mechanism for the activation of non-mutagenic chemicals. In this research, we show that the isothiocyanate which is a non-mutagenicity substance of food origin can regulate the total amount of mRNA of P450.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] 15. Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants2013
Author(s)
Uno,T.,Obe,Y.,Ogura,C.,Goto,T.,Yamamoto,K.,Nakamura,M.,Kanamaru,K.,Yamagata,H.,Imaishi,H
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Journal Title
Biopharm Drug Dispos
Volume: 1
Pages: 1-1
Related Report
Peer Reviewed
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[Journal Article] Metabolism of 7-ethoxycoumarin, safrole, flavanone and hydroxyflavanone by cytochrome P450 2A6 variants2012
Author(s)
Uno, T., Obe, Y., Ogura, C., Goto, T., Yamamoto, K., Nakamura, M., Kanamaru, K., Yamagata, H., Imaishi, H
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Journal Title
Biopharm. Drug Dispos
Volume: 34 (2)
Pages: 87-97
Related Report
Peer Reviewed
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[Journal Article] Photo-regulation of cytochrome P450 activity by using caged compound2012
Author(s)
Morigaki,K.,Mizutani,K.,Kanemura,E.,Tatsu,Y.,Yumoto,N.,Imaishi,H.
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Journal Title
Anal. Chem.
Volume: 84
Pages: 155-160
Related Report
Peer Reviewed
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[Journal Article] Metabolism of the herbicides chlorotoluron, diuron, linuron, simazine,and atrazine by CYP1A9 and CYP1C1 from Japanese eel (Anguilla japonica)2011
Author(s)
Uno,T.,Kajia,S.,Goto,T.,Imaishi, H.,
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Journal Title
Pesticide Biochemistry and Physiology
Volume: 101
Pages: 93-102
Related Report
Peer Reviewed
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[Journal Article] Vertically integrated human P450 and oxygen sensing film for the assays of P450 metabolic activities2011
Author(s)
Chang,G.,Morigaki,K.,Tatsu,Y.,Hikawa,T.,Goto,T.,Imaishi,H.
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Journal Title
Anal. Chem.
Volume: 83
Pages: 2956-2963
Related Report
Peer Reviewed
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[Presentation] Metablic activation of food-composition by human P450 variants representing single nucleotide polumorphisms2011
Author(s)
Imaishi,H.,Goto,T.,Mori,T.,Hikawa,T.,Hatta,M.,Matui,M.
Organizer
36ｔｈ FEBS CONGRESS
Place of Presentation
イタリア
Related Report
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[Presentation] Metabolism and Medabolic Activation of Food-composition by Human P450 Variants Representing Single Nucleotide Polymorphisms2011
Author(s)
Imaishi,H.,Goto,T.,Mori,T.,Hatta,M.,Matui,M.,Hikawa,T.
Organizer
17th North American Regional ISSX Meeting
Place of Presentation
アトランタ
Related Report
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