Development of Multifunctional Catalyst Operated byπ-Complexation Toward the Efficient Production of Enantioenriched Tetrasubstitutedα-Amino Acids.
| Project/Area Number |
23659015
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | 公益財団法人微生物化学研究会 |
|---|
Principal Investigator |
SHIBASAKI Masakatsu 公益財団法人微生物化学研究会, 微生物化学研究所, 所長 (30112767)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Naoya 公益財団法人微生物化学研究会, 微生物化学研究所・有機合成研究部, 主任研究員 (40431887)
|
|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
|
|---|
| Keywords | π結合 / アミノ酸 / 不斉4置換炭素 / 4置換アミノ酸 / 不斉合成 / 立体転写 |
|---|
| Research Abstract |
Designed catalysts bearing an electron-poorπ-complexation unit was synthesized and evaluated in π-complexation capability with substrates having an electron-donating. π-complexation unit by NMR analysis. Whereas a model catalyst lacking catalytically active site as a Bronsted base produced aπ-complex, a catalyst armed with a catalytic functionality failed to form theπ-complex. A new design for properly separating theπ-complexation unit and the catalytic site would lead to an effective catalytic system.
|
Report
(2 results)
Research Products
(4 results)
