| Project/Area Number |
23659015
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | 公益財団法人微生物化学研究会 |
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Principal Investigator |
SHIBASAKI Masakatsu 公益財団法人微生物化学研究会, 微生物化学研究所, 所長 (30112767)
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| Co-Investigator(Kenkyū-buntansha) |
KUMAGAI Naoya 公益財団法人微生物化学研究会, 微生物化学研究所・有機合成研究部, 主任研究員 (40431887)
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| Project Period (FY) |
2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | π結合 / アミノ酸 / 不斉4置換炭素 / 4置換アミノ酸 / 不斉合成 / 立体転写 |
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| Research Abstract |
Designed catalysts bearing an electron-poorπ-complexation unit was synthesized and evaluated in π-complexation capability with substrates having an electron-donating. π-complexation unit by NMR analysis. Whereas a model catalyst lacking catalytically active site as a Bronsted base produced aπ-complex, a catalyst armed with a catalytic functionality failed to form theπ-complex. A new design for properly separating theπ-complexation unit and the catalytic site would lead to an effective catalytic system.
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