Design of X-ray responsive drug carriers composed of oligodeoxynucleotides
| Project/Area Number |
23659020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
TANABE Kazuhito 京都大学, 大学院・工学研究科, 准教授 (40346086)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ドラッグデリバリー / 生物有機化学 / ドラッグキャリア / 両親媒性DNA / 会合体形成 / クリック反応 / X線照射 / インドールキノン / PEG / 両親媒性分子 |
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| Research Abstract |
Stimuli-responsive nanocarriers offer favorable properties for target-specific delivery of drugs. The carriers keep the toxic drugs encapsulated in their hydrophobic core, while the drugs can be readily released and exhibit their original toxicity once appropriate stimuli are applied. Here, we prepared novel drug carriers consisted of DNA oligomer and radiation-activated carriers.
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Report
(3 results)
Research Products
(10 results)
