| Project/Area Number |
23659061
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | 独立行政法人医薬基盤研究所 |
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Principal Investigator |
KAMADA Haruhiko 独立行政法人医薬基盤研究所, サブプロジェクトリーダー (00324509)
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
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| Keywords | 医薬分子設計 / バイオテクノロジー / インターフェロン / ファージ表面提示法 / 構造変異タンパク質 / タンパク質工学 |
|---|
| Research Abstract |
In this study, we focused on lead discovery for new interferon(IFN) therapy using structural mutant, which increase the activity and decrease the side-effects in vivo. We obtained 38 IFNα8 mutants, which have different binding activities for IFN receptor to perform the screening from IFN mutant library. Among these mutants, we found 4 mutant IFNs have superior activities than wild-type IFNα8.In future, we will utilize these mutant IFNs to create a new biopharmaceuticals by analyzing the mechanisms of increasing activity.
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