MVB sorting system as a novel defense mechanism against toxicity of cadmium

Research Project

Project/Area Number	23659062
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Environmental pharmacy
Research Institution	Tohoku University
Principal Investigator	NAGANUMA Akira 東北大学, 大学院・薬学研究科, 教授 (80155952)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	カドミウム / MVBソーティングシステム / 酵母 / 毒性軽減機構 / 液胞
Research Abstract	We examined the relationship of each protein, which is a member of the MVB sorting system on endosome, and cadmium toxicity using yeast cells. Deletion of each gene for all member protein of the system conferred hypersensitivity to cadmium toxicity. This result suggested that certain substrate protein(s) of this system plays a role in reduction of cadmium toxicity. Moreover, it was indicated that the substrate protein(s) is transported to the endosome through Golgi body from endoplasmic reticulum.

Report

(3 results)