Establishment of chrono-exercise on mouse experiment

• Project/Area Number: 23659126
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: SHIBATA Sigenobu 早稲田大学, 理工学術院, 教授 (10162629)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 体内時計 / 運動 / 時間栄養学 / 肥満 / エネルギー代謝 / 週刊栄養学 / 時刻 / グルコース / 骨格筋 / 週間

Research Abstract

It is well known that circadian clock system operates in whole body including peripheral organs. Previously we found bigger supper caused obesity in comparison with bigger breakfast in mice, suggesting that timing of food is important. Here we examined the timing of exercise as wheel-running on obesity and energy metabolism in mice. Exercise in the evening rather than in the morning protects the obesity and increases lipid metabolism. Feeding followed with exercise caused anti-obesity effect than exercise followed with feeding. These results suggest the importance of timing of exercise on obesity.

Research Products

• [Journal Article] Time-restricted feeding of rapidly digested starches causes stronger entrainment of the liver clock in PER2::LUCIFERASE knock-in mice. (2013)
  • Author(s): Itokawa M.
  • Journal Title: Nutrition Research Volume: 33 Issue: 2 Pages: 109-119
  • DOI: 10.1016/j.nutres.2012.12.004
  • Peer Reviewed
• [Journal Article] Meal frequency patterns determine the phase of mouse peripheral circadian clocks. (2012)
  • Author(s): Kuroda H, Tahara Y, Saito K, Ohnishi N, Kubo Y, Seo Y, Otsuka M, Fuse Y, Ohura Y, Hirao A, Shibata S.
  • Journal Title: Scientific Reports. Volume: 2 Pages: 711-711
  • URL: http://www.nature.com/srep/index.html
  • Peer Reviewed
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice. (2012)
  • Author(s): Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S
  • Journal Title: Br J Dermatol.
  • Peer Reviewed
• [Journal Article] Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. (2012)
  • Author(s): Fuse Y, Hirao A, Kuroda H, Otsuka M, Tahara Y, Shibata S.
  • Journal Title: J Circadian Rhythms. Volume: 10(1) Pages: 4-4
  • URL: http://www.jcircadianrhythms.com/
  • Peer Reviewed
• [Journal Article] In vivo monitoring of peripheral circadian clocks in the mouse. (2012)
  • Author(s): Tahara Y, Kuroda H, Saito K, Shibata S.
  • Journal Title: Current Biology Volume: 22 Pages: 1029-34
  • URL: http://www.cell.com/current-biology/
  • Peer Reviewed
• [Journal Article] Involvement of the stress kinase mitogen-activated protein kinase kinase 7 in the regulation of the mammalian circadian clock. (2012)
  • Author(s): Uchida Y, Osaki T, Yamasaki T, Shimomura T, Hata S, Horikawa K, Shibata S, Todo T, Hirayama J, Nishina H.
  • Journal Title: J Biol Chem. Volume: 287(11) Pages: 8318-26
  • URL: http://www.jbc.org/
  • Peer Reviewed
• [Journal Article] The Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice. (2012)
  • Author(s): Hirao A, Furutani N, Nagahama H, Itokawa M, Shibata S.
  • Journal Title: Food Nutrition and Sciences Volume: 3(1) Pages: 40-47
  • URL: http://www.scirp.org/journal/fns/
  • Peer Reviewed
• [Journal Article] 2,2,2-Tribromoethanol phase-shifts the circadian rhythm of the liver clock in Per2 : Luciferase knockin mice : lack of dependence on anesthetic activity. (2012)
  • Author(s): Kubo Y, Tahara Y, Hirao A, Shibata S.
  • Journal Title: J Pharmacol Exp Ther. Volume: 340(3) Pages: 698-705
  • URL: http://jpet.aspetjournals.org/
  • Peer Reviewed
• [Journal Article] 時間栄養学 (2012)
  • Author(s): 柴田重信、青木菜摘
  • Journal Title: G. I. Research Volume: vol.20 no.5
  • NAID: 10031123205
• [Journal Article] 栄養-評価と治療- (2012)
  • Author(s): 柴田重信
  • Journal Title: 用語解説「時間栄養学」 Volume: Vol29 No.3
• [Journal Article] 体内時計を用いた理想的な食生活作りのために (2012)
  • Author(s): 平尾彰子、柴田重信
  • Journal Title: 顕微鏡 Volume: 第47巻第2号 Pages: 83-86
  • NAID: 10030794049
  • URL: http://www.microscopy.or.jp/magazine/microscopy.html
• [Journal Article] 暮らしの最前線90「時間栄養学の現状とこれから」 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本家政学会誌 Volume: 第63巻第6号 Pages: 337-341
  • Peer Reviewed
• [Journal Article] 生体リズムと創薬 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本臨床薬理学会誌
  • NAID: 10030573970
• [Journal Article] 概日リズムと肥満・生活習慣病、「体内時計と栄養・食事の相互作用」 (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本肥満学会誌
  • URL: http://www.jasso.or.jp/contents/magazine/index.html
• [Journal Article] 時計遺伝子と食事リズム-時間栄養学- (2012)
  • Author(s): 柴田重信
  • Journal Title: 日本臨床栄養学会誌
  • URL: http://www.jscn.gr.jp/activities/gakkaishi/index.html
• [Journal Article] Biological clock dysfunction exacerbates contact hypersensitivity in mice. (2012)
  • Author(s): Takita E, Yokota S, Tahara Y, Hirao A, Aoki N, Nakamura Y, Nakao A, Shibata S
  • Journal Title: British Journal of Dermatology Volume: 168 Issue: 1 Pages: 39-46
  • DOI: 10.1111/j.1365-2133.2012.11176.x
  • Peer Reviewed
• [Journal Article] In Vivo Monitoring of Peripheral Circadian Clocks in the Mouse (2012)
  • Author(s): Tahara Y, Kuroda H, Saito K, Nakajima Y, Kubo Y, Ohnishi N, Seo Y, Otsuka M, Fuse Y, Ohura Y, Komatsu T, Moriya Y, Okada S, Furutani N, Hirao A, Horikawa K, Kudo T, Shibata S
  • Journal Title: Current Biology Volume: 22 Issue: 11 Pages: 1029-1034
  • DOI: 10.1016/j.cub.2012.04.009
  • Peer Reviewed
• [Journal Article] Protective and Recovery Effects of Fish Oil Supplementation on Cedar Pollen-Induced Allergic Reactions in Mice (2012)
  • Author(s): Akiko Hirao, Naoki Furutani, Hiroki Nagahama, Misa Itokawa, Shigenobu Shibata
  • Journal Title: Food Nutrition and Sciences Volume: 3 Pages: 40-47
  • Peer Reviewed
• [Journal Article] 時間栄養学、化学と生物
  • Author(s): 柴田重信
  • Journal Title: 日本農芸化学会誌 Volume: 2012
  • Peer Reviewed
• [Presentation] マウス体内時計遺伝子をリセットする食餌内容の研究 (2012)
  • Author(s): 柴田重信
  • Organizer: (財)飯島記念食品科学振興財団第25回学術講演会
  • Place of Presentation: 東京(学士会館)
  • Year and Date: 2012-11-22
• [Presentation] 時間薬理学・時間栄養学の視点の生活習慣病 (2012)
  • Author(s): 柴田重信
  • Organizer: 平成24年度メタボリックシンドローム予防のための健康セミナー
  • Place of Presentation: 大分(大分商工会議所)
  • Year and Date: 2012-11-10
• [Presentation] 時間栄養学-食の内容から食べ方まで- (2012)
  • Author(s): 柴田重信
  • Organizer: 第20回日本植物油協会植物油栄養懇話会
  • Place of Presentation: 東京(如水会館)
  • Year and Date: 2012-11-09
• [Presentation] 体内時計と栄養 (2012)
  • Author(s): 柴田重信
  • Organizer: 第6回順天堂Kampo先端治療研究会
  • Place of Presentation: 東京(順天堂大学)
  • Year and Date: 2012-11-07
• [Presentation] 時間栄養学～免疫・炎症から代謝障害まで～ (2012)
  • Author(s): 柴田重信
  • Organizer: 第5回基礎と臨床を結ぶ分子病態研究会
  • Place of Presentation: 東京(学士会館)
  • Year and Date: 2012-10-27
• [Presentation] マウス絶食性脂肪肝はAChE阻害剤により増強する (2012)
  • Author(s): 柴田重信、横田伸一、中村果愛、青木菜摘
  • Organizer: 第127回日本薬理学会関東部会
  • Place of Presentation: 東京(東京国際フォーラム)
  • Year and Date: 2012-10-20
• [Presentation] 中枢神経系と肥満研究のフォロンティア「時間栄養学と肥満・代謝障害」 (2012)
  • Author(s): 柴田重信
  • Organizer: 第33回日本肥満学会
  • Place of Presentation: 京都(ホテルグランヴィア京都)
• [Presentation] インビボとインビトロで調べた末梢時計の相違と特徴 (2012)
  • Author(s): 柴田重信
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道(北海道大学学術交流会館)
• [Book] 「サーカディアンシグナリング」、イラストで徹底理解するシグナル伝達キーワード事典 (2012)
  • Author(s): 堀川和政、柴田重信
  • Publisher: 羊土社
• [Remarks]
  • URL: http://www.eb.waseda.ac.jp/shibata/