A study on the role of NOX1/NADPH oxidase in cardiac arrhythmia

Research Project

Project/Area Number	23659140
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	General pharmacology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	YABE Chihiro 京都府立医科大学, 大学院・医学研究科, 教授 (70150571)
Co-Investigator(Kenkyū-buntansha)	IWATA Kazumi 京都府立医科大学, 医学研究科, 講師 (60305571) MSATSUMOTO Misaki 京都府立医科大学, 医学研究科, 助教 (80533926) CHOU Ka 京都府立医科大学, 医学研究科, プロジェクト研究員 (50599222) 松野邦晴京都府立医科大学, 医学(系)研究科(研究院), 助教 (50420708)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords	循環器・高血圧 / 不整脈 / チャネル / 活性酸素種
Research Abstract	Reactive oxygen species (ROS) have been implicated in the pathogenesis of atrial fibrillation by affecting ion channels of cardiomyocytes. In animal model of sepsis, susceptibility to cardiac arrhythmia is augmented. Since we previously demonstrated that a novel isoform of superoxide-generating NADPH oxidase, NOX1, was up-regulated in septic heart to elicit cardiomyocyte apoptosis, a possible involvement of NOX1 in the development of cardiac arrhythmia was investigated using mice deficient in Nox1.