| Project/Area Number |
23659145
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
DEZAWA Mari 東北大学, 大学院・医学系研究科, 教授 (50272323)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 多能性幹細胞 / 繊維芽細胞 / 間葉系幹細胞 / 造血細胞 / 骨髄 / 分化転換 |
|---|
| Research Abstract |
Human dermal fibroblast-derived Muse cells, a type of pluripotent stem cells (Kuroda et al., PNAS, 2010), were infused into X-ray irradiated SICD mouse via tail vein. Six months after, cells positive for human leukocyte, lymphocytes markers were detected in theperipheral blood of the mice. In the bone marrow, GFP-labeled Muse cells were suggested to be differentiated into pre-erythroblast marker CD235a-positive cells. Pluripotent Muse cells that can be harvested from mesenchymal tissues are suggested to be applicable to bone marrow transplantation.
|
