Possibility of transplantation of human skin-derived pluripotent stem cells into the bone marrow
| Project/Area Number |
23659145
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
DEZAWA Mari 東北大学, 大学院・医学系研究科, 教授 (50272323)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多能性幹細胞 / 繊維芽細胞 / 間葉系幹細胞 / 造血細胞 / 骨髄 / 分化転換 |
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| Research Abstract |
Human dermal fibroblast-derived Muse cells, a type of pluripotent stem cells (Kuroda et al., PNAS, 2010), were infused into X-ray irradiated SICD mouse via tail vein. Six months after, cells positive for human leukocyte, lymphocytes markers were detected in theperipheral blood of the mice. In the bone marrow, GFP-labeled Muse cells were suggested to be differentiated into pre-erythroblast marker CD235a-positive cells. Pluripotent Muse cells that can be harvested from mesenchymal tissues are suggested to be applicable to bone marrow transplantation.
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Report
(3 results)
Research Products
(142 results)
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
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Journal Title
J Clin Invest
Volume: 123(1)
Issue: 1
Pages: 272-284
DOI
Related Report
Peer Reviewed
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[Journal Article] Autologous engraftment of A9 dopaminergic neurons induced from mesenchymal stem cells in parkinsonian rhesus macaques.2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.
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Journal Title
J. Clin. Invest.
Volume: 123(1)
Pages: 272-284
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transaction2012
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera J.J, Kawashima R, TominagaT, Dezawa M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transaction.2012
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera J.J, Kawashima R, Tominaga T, Dezawa M.
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Journal Title
Cell Transplantation
Volume: 掲載確定
Related Report
Peer Reviewed
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[Journal Article] Multiliineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fijiyoshi Y, Dezawa M
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Journal Title
Proc.Natl.Acad.Sci.U.S.A.
Volume: 108(24)
Issue: 24
Pages: 9875-9880
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord2011
Author(s)
Kamada T, Koda M, Dezawa M, ara R, Toyama Y, Yoshinaga K, Hashimoto M, Koshizuka S, Nishio Y, Mannoji C, Okawa A, Yamazaki M
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Journal Title
Neuropathology
Volume: 31(1)
Issue: 1
Pages: 48-58
DOI
Related Report
Peer Reviewed
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[Journal Article] Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts.2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, Dezawa M.
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 108(24)
Pages: 9875-9880
Related Report
Peer Reviewed
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