Gain more insight, perform the following genome-wide association studies in Japanese, counterargument to the study that need correct re-diagnosis by Europe-an study
Project/Area Number |
23659160
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
TASHIRO Kei 京都府立医科大学, 大学院・医学研究科, 教授 (10263097)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | ゲノム医化学 / 遺伝子 / 落屑緑内障 / GWAS / ゲノムワイド関連解析 |
Research Abstract |
We examined our two data sets of the genome-wide association studies (GWAS) derived from a Japanese population was strictly classified as glaucoma and controls with detail examination and diagnosis. We performed a GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs) in 833 POAG patients and 686 controls. We then subdivided the case groups into two subtypes based on the value of intraocular pressure (IOP) -POAG with high IOP (high Pressure glaucoma, HPG) and that with normal IOP (normal pressure glaucoma, NPG) performed the GWAS. The results suggested that the variants from CDKN2B-AS1 locus were likely to be significant for NPG patients (PLoS ONE: 7: e33389, 2012).On the other hand we performed a case-control study using 190 Japanese exfoliation glaucoma (XFG) patients and 660 controls.It is currently under consideration of replication study of the association to identify specific marker for XFG.
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Identification of a novel gene by whole human genome tiling array.2013
Author(s)
Ishida H, Yagi T, Tanaka M, Tokuda Y, Kamoi K, Hongo F, Kawauchi A, Nakano M, Miki T, Tashiro K
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Journal Title
Gene, Peer-Reviewed papers
Volume: 516(1)
Issue: 1
Pages: 33-38
DOI
Related Report
Peer Reviewed
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[Journal Article] Epistatic interaction between Toll-like receptor 3 (TLR3) and prostaglandin E receptor 3 (PTGER3) genes2012
Author(s)
Ueta M, Tamiya G, Tokunaga K, Sotozono C, Ueki M, Sawai H, Inatomi T, Matsuoka T, Akira S, Narumiya S, Tashiro K, Kinoshita S
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Journal Title
J Allergy Clin Immunol Peer-Reviewed papers
Volume: 129(5)
Issue: 5
Pages: 1413-1416
DOI
Related Report
Peer Reviewed
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[Presentation] Analysis of Hematological and Biochemical Data in Primary Open‐Angle Glaucoma Patients2012
Author(s)
Maruyama, Y., Mori, K., Yoshii, H., Yoshikawa, H., Ikeda, Y., Ueno, M., Tashiro, K., Kinoshita, S.
Organizer
Asia Pacific Glaucoma Congress
Place of Presentation
Bali,Indonesia
Related Report
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[Presentation] Common genetic variants of primary open-angle glaucoma in Japanese Population2012
Author(s)
Nakano, M., Ikeda., Y, Tokuda, Y., Fuwa, M., Omi, N., Adachi, H., Ueno, M., Mori, K., Kinoshita, S. and Tahiro, K
Organizer
62nd Annual Meeting of the American Society of Human Genetics
Place of Presentation
San Francisco, USA
Related Report
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[Presentation] 原発開放隅角緑内障患者における血液生化学データの解析2012
Author(s)
吉井健吾, 池田陽子, 森 和彦, 上野盛夫, 丸山悠子, 吉川晴菜, 中野正和, 見奈津江, 徳田雄市, 田代啓, 木下 茂
Organizer
第23回日本緑内障学会
Place of Presentation
金沢
Related Report
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[Presentation] Association of risk alleles of glaucoma marker SNPs with morphological characters of the optic disc2012
Author(s)
Ikeda, Y., Mori, K., Ueno, M., Imai, K., Nakano, M., Fuwa, M., Yoshii, K., Yagi, Y., Tokuda, Y., Tashiro, K. and Kinoshita, S.
Organizer
10th Congress of the European Glaucoma Society. Copenhagen
Place of Presentation
Denmark
Related Report
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[Presentation] Genome-wide association study on primary open- angle glaucoma with a 1000K gene chip.2012
Author(s)
Mori, K., Ikeda, Y., Ueno, M., Imai, K., Nakano, M., Tokuda, Y., Omi, N., Adachi, H., Tashiro, K. and Kinoshita, S.
Organizer
Annual Meeting of the Association for Research in Vision and Ophthalmology.
Place of Presentation
Florida, USA
Related Report
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[Presentation] Genome-wide association study on primary open-angle glaucoma with a 1000K gene chip.2012
Author(s)
Mori, K., Ikeda, Y., Ueno, M., Imai, K., Nakano, M., Tokuda, Y., Omi, N., Adachi, H., Tashiro, K. and Kinoshita, S.
Organizer
Annual Meeting of the Association for Research in Vision and Ophthalmology
Place of Presentation
Florida, USA
Related Report
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[Presentation] Association of risk alleles of glaucoma marker SNPs with morphological characters of the optic disc2012
Author(s)
Ikeda Y, Mori K, Ueno M, Imai K, Nakano M, Fuwa M, Yoshii K, Yagi Y, Tokuda Y, Tashiro K, and Kinoshita S.
Organizer
10th Congress of the European Glaucoma Society
Place of Presentation
Copenhagen
Related Report
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[Presentation] 正常者における緑内障疾患マーカーSNPと血液生化学データの関連性の検討2011
Author(s)
池田陽子, 吉井健悟, 森和彦, 上野盛夫, 中野正和, 徳田雄市, 大見奈津江, 八木知人, 今井浩二郎, 田代啓, 木下茂
Organizer
第22回日本緑内障学会
Place of Presentation
秋田
Related Report
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[Presentation] Association Between General Systematic Disease and the Marker Snps for Primary Open-Angle Glaucoma.2011
Author(s)
Ikeda Y, Mori K, Ueno M, Imai K, Yagi T, Omi N, Tokuda Y, Fuwa M, Tashiro K,Kinoshita S
Organizer
World Glaucoma Congress
Place of Presentation
Paris, France
Related Report
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[Presentation] 原発開放隅角緑内障関連遺伝子に対するカスタムチップ解析2011
Author(s)
池田陽子, 森和彦, 上野盛夫, 今井浩二郎, 不破正博, 中野正和, 谷口孝純, 徳田雄市, 大見奈津江, 八木知人, 田中雅深, 田代啓, 木下茂
Organizer
原発開放隅角緑内障関連遺伝子に対するカスタムチップ解析
Place of Presentation
東京
Related Report
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[Presentation] Candidate gene analysis of primary open-angle glaucoma in a Japanese population using a custom chip.2011
Author(s)
Ikeda, Y., Mori, K., Ueno, M., Imai, K., Fuwa, M., Tokuda, Y., Nakano, M., Yagi, T., Tashiro, K. and Kinoshita, S
Organizer
Annual Meeting of the Association for Research in Vision and Ophthalmology
Place of Presentation
Florida, USA
Related Report
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[Presentation] Candidate Gene Analysis of Primary Open-Angle Glaucoma in a Japanese Population using a Custom Chip2011
Author(s)
Ikeda Y, Mori K, Ueno M, Imai K, Fuwa M, Yokuda, Y, Nakano M, Yagi T, Tahiro K, Kinoshita S.
Organizer
The Association for Research in Vision and Ophthalmology
Place of Presentation
Florida
Related Report
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[Presentation] Candidate Gene Analysis of Primary Open-Angle Glaucoma in a Japanese Population using a Custom Chip2011
Author(s)
Ikeda Y, Mori K, Ueno M, Imai K, Fuwa M, Yokuda, Y, Nakano M, Yagi T, Tahiro K, Kinoshita S.
Organizer
World Glaucoma Congress
Place of Presentation
Paris
Related Report
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