| Project/Area Number |
23659160
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TASHIRO Kei 京都府立医科大学, 大学院・医学研究科, 教授 (10263097)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ゲノム医化学 / 遺伝子 / 落屑緑内障 / GWAS / ゲノムワイド関連解析 |
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| Research Abstract |
We examined our two data sets of the genome-wide association studies (GWAS) derived from a Japanese population was strictly classified as glaucoma and controls with detail examination and diagnosis. We performed a GWAS by analyzing 653,519 autosomal common single-nucleotide polymorphisms (SNPs) in 833 POAG patients and 686 controls. We then subdivided the case groups into two subtypes based on the value of intraocular pressure (IOP) -POAG with high IOP (high Pressure glaucoma, HPG) and that with normal IOP (normal pressure glaucoma, NPG) performed the GWAS. The results suggested that the variants from CDKN2B-AS1 locus were likely to be significant for NPG patients （PLoS ONE: 7: e33389, 2012）.On the other hand we performed a case-control study using 190 Japanese exfoliation glaucoma (XFG) patients and 660 controls．It is currently under consideration of replication study of the association to identify specific marker for XFG.
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