| Project/Area Number |
23659183
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ISHIDA Takanori 東北大学, 大学院・医学系研究科, 准教授 (00292318)
SUZUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
MIKI Yasuhiro 東北大学, 災害科学国際研究所, 講師 (50451521)
ONO Katsuhiko 東北大学, 大学院・医学系研究科, 技術専門 職員 (80466531)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 乳癌 / microRNA / LIN28 / Ki-67 / HER2 |
|---|
| Research Abstract |
A new molecular technique as a breast cancer diagnosis is attracting a great deal of attention. In this research, I clarified relation between miRNA expression and pathological biomarkers using breast cancer tissues. These main results of this research are as follows: 1) LIN28 correlated with let-7 family 2) Identification of miRNAs relatedwith Ki-67, which is proliferation marker. and 3) Identification of miRNAs related with HER2, which is targeting molecule for breast cancer therapy. The results from our research suggest the possibility of the miRNA analysis as an novel diagnosis tool for breast cancer.
|
