Molecular mechanism of pathogenic network for the onset of joint ankylosis with psoriatic dermatitis
| Project/Area Number |
23659198
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
ONO Masao 東北大学, 大学院・医学系研究科, 教授 (20302218)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 強直症 / 皮膚炎 / IL-17 / 疾患モデル / 治療実験 / 抗サイトカイン療法 |
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| Research Abstract |
Ankylosing arthropathy, such as ankylosing spondylitis, psoriatic arthritis, and so forth, are intractable joint diseases with present therapeutic approaches to other arthropathic disorders. To develop a new effective approach to ankylosing arthropathy, it is necessary to clarify an essential pathogenic mechanism of ankylosis and to obtain evidence for efficacy of a new therapeutic approach in an animal disease model. My previous study had characterized a proper mouse model for the study of human ankylosing diseases. The present study using experimental strains of mice with spontaneous onset of ankylosis showed genetic association of the ankylosis onset, pathogenic contribution of testis to male preponderance of this onset, histopathological characteristics of early to late phases after the ankylosis onset, and therapeutic efficacy of anti-IL-17 administration.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Presumptive role of129 strain-derived Sle16 locus in rheumatoid arthritis in a new mouse model with Fcγ receptor type IIb-deficient C57BL/6 genetic background2011
Author(s)
Sato-Hayashizaki A, Ohtsuji M, Lin Q, Hou R, Ohtsuji N, Nishikawa K, Tsurui H, Sudo K, Ono M, Izui S, Shirai T, Takai T, Nishimura H, Hirose S
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Journal Title
Arthritis Rheum
Volume: 63
Pages: 2930-2938
Related Report
Peer Reviewed
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[Journal Article] Indispensable roles ofOX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension2011
Author(s)
Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M
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Journal Title
BMC Immunology
Volume: 12
Pages: 67-78
Related Report
Peer Reviewed
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[Journal Article] Indispensable roles of OX40L-derived signal and epistatic genetic effect in immune-mediated pathogenesis of spontaneous pulmonary hypertension.2011
Author(s)
Rabieyousefi M, Soroosh P, Satoh K, Date F, Ishii N, Yamashita M, Oka M, McMurtry IF, Shimokawa H, Nose M, Sugamura K, Ono M.
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Journal Title
BMC Immunol.
Volume: 12
Pages: 67-78
Related Report
Peer Reviewed
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