| Project/Area Number |
23659204
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAKASHITA Naomi 徳島大学, ヘルスバイオサイエンス研究部, 教授 (90284752)
菰原 義弘 熊本大学, 大学院生命科学研究部(医), 講師 (40449921)
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| Co-Investigator(Renkei-kenkyūsha) |
FUJIWARA Yukio 熊本大学, 生命科学研究部, 助教 (70452886)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | マクロファージ / 古典的活性化 / オルタナティブ活性化 / 天然化合物 / corosolic acid / STAT3 / onionin A |
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| Research Abstract |
Macrophages are variously activated in disease environment. For example, M1-activated macrophages are involved in obesity and atherosclerosis, whereas M2-activated tumor-associated macrophages promote tumor progression. To develop new therapeutic strategies we identified several compounds that regulate M1- or M2-activation of macrophages by screening the library of natural compounds. Among them, colosolic acid and onionin A suppressed tumor progression by means of suppressing STAT3 activation. These two compounds significantly suppressed subcutaneous tumor development and lung metastasis in a murine sarcoma model. Through these results, application of colosolic acid and onionin A is considered a potential new anticancer therapy targeting macrophage activation.
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