| Project/Area Number |
23659226
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | 防衛医科大学校 (2012)
National Defense Medical College (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ONO Satoshi 防衛医科大学校, 防衛医学研究センター, 准教授 (30531355)
KINOSITA Manabu 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (70531391)
SAITO Daizoh 防衛医科大学校, 防衛医学研究センター, 教授 (90531632)
SAKAMOTO Toshihisa 防衛医科大学校, 病院, 教授 (50178571)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 病原性 / Helicobacter pylori / 胃内起因菌 / 胃がん細胞 / Proteus mirabillis / cell proliferation / MKN45 |
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| Research Abstract |
Helicobacter pylori infection of the stomach is related to the development of diverse gastric pathologies. However, it is still unclear whether Helicobacter pylori would augment their virulence factor when other gastric bacteria existed together with Helicobacter pylori in stomach. To address this question, we investigated the cell proliferation and gene expression of both TLR4 and TLR5 of cancer cell line AGS under coexistence with another gastric bacteria Proteus mirabilis. We need further research in detail, but the results showed that Helicobacter pylori may augment gene expressions of TLR4 and TLR5 on cancer cells under coexistence with Proteus mirabilis.
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