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Understanding of neuronal mechanisms of chronic pain

Research Project

Project/Area Number 23659318
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionOsaka University

Principal Investigator

TOYODA Hiroki  大阪大学, 歯学研究科(研究院), 准教授 (00432451)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords慢性疼痛 / 帯状回 / シナプス / 興奮伝播 / EPSC / グルタミン酸受容体 / 帯状回皮質 / シナプス伝達
Research Abstract

The anterior cingulate cortex (ACC) is a forebrain structure that plays important roles in emotion, learning, memory and persistent pain. However, little is known about the neuronal mechanisms about chronic pain. In the present study, the quantal analysis of excitatory synapses in the ACC revealed that both probability of transmitter release and number of available vesicles were increased in a mouse model of peripheral inflammation. The voltage-sensitive dye imaging also revealed that the horizontal excitation spread in L2/3 caused by L4 stimulation in the ACC was enhanced in the mouse model of peripheral inflammation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2013 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (20 results)

  • [Journal Article] A mathematical model of negative covariability of inter-columnar excitatory synaptic actions caused by presynaptic inhibition2013

    • Author(s)
      Saito M, Tanaka T, Sato H, Toyoda H, Aoyagi T, Kang Y
    • Journal Title

      The European Journal of euroscience

      Volume: 38 Issue: 7 Pages: 2999-3007

    • DOI

      10.1111/ejn.12299

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] GABAB receptor-mediated presynaptic inhibition reverses inter-columnar covariability of synaptic actions by intracortical axons in the rat barrel cortex2013

    • Author(s)
      Sato H, Toyoda H, Saito M, Kobayashi M, Althof D, Kulik A, Kang Y
    • Journal Title

      The European Journal of Neuroscience

      Volume: 37 Issue: 2 Pages: 190-202

    • DOI

      10.1111/ejn.12041

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Illusion caused by vibration of muscle spindles reveals an involvement of muscle spindle inputs in regulating isometric contraction of masseter muscles2012

    • Author(s)
      Tsukiboshi T, Sato H, Tanaka Y, Saito M, Toyoda H, Morimoto T, Tiirker KS, Maeda Y, Kang Y
    • Journal Title

      Journal of Neurophysiology

      Volume: 108 Issue: 9 Pages: 2524-2533

    • DOI

      10.1152/jn.00997.2011

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Capsaicin induces theta-band synchronization between gustatory and autonomic insular cortices2012

    • Author(s)
      Saito M, Toyoda H, Kawakami S, Sato H, Bae YC, Kang Y.
    • Journal Title

      The Journal of Neuroscience

      Volume: 32 Issue: 39 Pages: 13470-13487

    • DOI

      10.1523/jneurosci.5906-11.2012

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Up-regulation of CREB-mediated transcription enhances both short- and long-term memory2011

    • Author(s)
      Suzuki, A., Fukushima, H., Takuya Mukawa, T., Toyoda, H., Wu, L-J., Zhao, M-G., Hui Xu, H., Shane, Y., Endoh, K., Iwamoto, Mamiya, N., Okano, E., Hasegawa, H., Mercaldo, V., Yue Zhang, Y., Maeda, R., Ohta, M., Josselyn, S.A., Zhuo, M., Kida, S.
    • Journal Title

      J.Neurosci.

      Volume: 31 Issue: 24 Pages: 8786-8802

    • DOI

      10.1523/jneurosci.3257-10.2011

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Phospholipase C-related inactive proteins are involved in the regulation of phasic and tonic inhibition in the barrel cortex2013

    • Author(s)
      Toyoda, H., Saito, M., Sato, H., Kanematsu, T., Hirata, M. and Kang, Y
    • Organizer
      The 43rd Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2013-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] PRIP1/2 蛋白の発現抑制はバレル皮質錐体細胞において一過性GABA 抑制を強化する2013

    • Author(s)
      豊田博紀, 齋藤充, 佐藤元, 兼松隆, 平田雅人, 姜英男
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Phospholipase C-related inactive protein regulates the Phasic and tonic inhibition in the barrel cortex2013

    • Author(s)
      Toyoda, H., Saito, M., Sato, H., Kanematsu, T., Hirata, M. and Kang, Y
    • Organizer
      The 11lth Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      Hamamatsu
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] バレル皮質錐体細胞においてPRIP 遺伝子欠損により細胞外シナプスGABAA 受容体の発現が増加する2013

    • Author(s)
      豊田博紀, 齋藤充, 佐藤元, 兼松隆, 平田雅人, 姜英男
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] バレル皮質錐体細胞においてPRIP 遺伝子欠損によりGABAA 電流の鋭感作および再感作が増強する2013

    • Author(s)
      豊田博紀, 小川丈夫, 佐藤元, 齋藤充, 兼松隆, 平田雅人, 姜英男
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2013-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] バレル皮質錐体細胞においてPRIP遺伝子欠損により細胞外シナプスGABAA受容体の発現が増加する2013

    • Author(s)
      豊田博紀 他
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都国際会館(京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phospholipase C-related inactive protein regulates the phasic and tonic inhibition in the barrel cortex2013

    • Author(s)
      Toyoda, H. et al
    • Organizer
      The 11th Japan-Korea Joint Symposium of Brain Sciences, and Cardiac and Smooth Muscles
    • Place of Presentation
      浜松アクトシティ(浜松)
    • Related Report
      2013 Annual Research Report
  • [Presentation] PRIP1/2蛋白の発現抑制はバレル皮質錐体細胞において一過性GABA抑制を強化する2013

    • Author(s)
      豊田博紀 他
    • Organizer
      第55回歯科基礎医学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phospholipase C-related inactive proteins are involved in the regulation of phasic and tonic inhibition in the barrel cortex2013

    • Author(s)
      Toyoda, H. et al
    • Organizer
      43rd Society for Neuroscience
    • Place of Presentation
      San Diego convention center(San Diego)
    • Related Report
      2013 Annual Research Report
  • [Presentation] バレル皮質錐体細胞においてPRIP遺伝子欠損によりGABA(A)電流の脱感作および再感作が増強する2013

    • Author(s)
      豊田博紀 他
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2012 Research-status Report
  • [Presentation] Phospholipase C-related inactive protein resensitization of GABA_A receptor currents in the barrel cortex2012

    • Author(s)
      Toyoda, H., Ogawa, T., Saito, M., Sato, H., Kanematsu, T., Hirata, M. and Kang, Y
    • Organizer
      The 42nd Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] PRIP 遺伝子欠損によりバレル皮質錐体細胞におけるGABAA 電流の脱感作および再感作が増強する2012

    • Author(s)
      豊田博紀, 小川丈夫, 齋藤充, 佐藤元, 兼松隆, 平田雅人, 姜英男
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-18
    • Related Report
      2013 Final Research Report
  • [Presentation] PRIP遺伝子欠損によりバレル皮質錐体細胞におけるGABA(A)電流の脱感作および再感作が増強する2012

    • Author(s)
      豊田博紀 他
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Related Report
      2012 Research-status Report
  • [Presentation] Phospholipase C-related inactive protein modulates desensitization and resensitization of GABAA receptor currents in the barrel cortex2012

    • Author(s)
      Toyoda, H. et al.
    • Organizer
      42th Society for Neuroscience
    • Place of Presentation
      Ernest N. Morial Convention Center (New Orleans, USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] cGMP differentially modulates leak K^+ currents in masseter motoneurons2011

    • Author(s)
      Toyoda, H., Hirao, K., Saito M., Sato, H and Kang, Y
    • Organizer
      The 41th Society for Neuroscience
    • Place of Presentation
      Washington, USA
    • Year and Date
      2011-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] バレル皮質におけるGABAA 受容体電流および興奮伝播に対するPRIP の役割2011

    • Author(s)
      豊田博紀, 小川丈夫, 齋藤充, 佐藤元, 兼松隆, 平田雅人, 姜英男
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Oscillatory neural synchronization between the gustatory and visceral insular cortices induced by activation of TRPVl in the gustatory area2011

    • Author(s)
      Toyoda, H. and Kang, Y
    • Organizer
      The 6th international conference of neurons and brain diseases
    • Place of Presentation
      Toyama
    • Year and Date
      2011-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Oscillatory neural synchronization between the gustatory and visceral insular cortices induced by activation of TRPV1 in the gustatory area2011

    • Author(s)
      Toyoda, H. et al.
    • Organizer
      The 6th international conference of Neurons and Brain diseases(招待講演)
    • Place of Presentation
      ANAクラウンプラザ富山(富山県)
    • Related Report
      2011 Research-status Report
  • [Presentation] cGMP differentially modulates leak K+ currents in masseter motoneurons2011

    • Author(s)
      Toyoda, H. et al.
    • Organizer
      41th Society for Neuroscience
    • Place of Presentation
      Washington convention center (Washington, USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] バレル皮質におけるGABA(A)受容体電流および興奮伝播に対するPRIPの役割2011

    • Author(s)
      Toyoda, H. et al.
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      長良川国際会議場(岐阜)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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