New classification of nociceptive sensory neurons and functional interaction between TRPV1 and TRPA1
Project/Area Number |
23659323
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pain science
|
Research Institution | 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設) (2012) National Institutes of Natural Sciences Okazaki Research Facilities (2011) |
Principal Investigator |
TOMINAGA Makoto 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 教授 (90260041)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 侵害受容器 / 疼痛学 |
Research Abstract |
We found that capsiate, an ingredient contained in non-pungent capsicum, activates TRPA1. We found that Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner. We found that two isothiocyanates from Wasabia japonica (6-MSITC, 6-MTITC) activate TRPA1. We found that 1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1 upon intensive screening.
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Report
(3 results)
Research Products
(12 results)