Development of new protective method against environmental factors.
| Project/Area Number |
23659324
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Hokkaido University |
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Principal Investigator |
FUJITA Hiroyoshi 北海道大学, 医学(系)研究科(研究院), 教授 (60142931)
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| Co-Investigator(Kenkyū-buntansha) |
WAKAO Hiroshi 北海道大学, 大学院医学研究科, 准教授 (10280950)
ODA Atsushi 北海道大学, 大学院医学研究科, 准教授 (50255436)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | MAIT細胞 / iPS化 / 多剤耐性菌対策 / 細胞治療 / 抗菌活性 / 抗酸菌 / ゲノム修飾のないiPS化 / 粘膜関連インバリアントT細胞 / 分化誘導 / NKT細胞 / さる胚性幹細胞 / レンチウイルスベクター / T細胞分化誘導 |
|---|
| Research Abstract |
We investigated anti-mycobacterial activity of human reMAIT cells. Immunocompromised mice received human reMAIT cells could resist against M. abscessus infection. reMAIT cells transfered mice demonstrated marked expression of granulysin whose gene was absent in mice, indicating that human reMAIT cells killed mycobacteria through granylysin. Hereby,a novel method against infectious diseases is demonstrated.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Expansion of functional human Mucosal-Associated Invariant T Cells via reprogramming to pluripotency and redifferentiation2013
Author(s)
H Wakao, K Yoshikiyo, U Koshimizu, T Furukawa, K Enomoto, T Matsunaga, T Tanaka, Y Yasutomi, T Yamada, H Minakami, J Tanaka, A Oda, T Sasaki, R Wakao, O Lantz, T Udagawa, Y Sekiya, K Higuchi, N Harada,K Nishimura, M Ohtaka, M Nakanishi and H Fujita
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Journal Title
Cell Stem Cell
Volume: 12
Pages: 546-558
Related Report
Peer Reviewed
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