To assess the risk of Attention Deficit/Hyper-Activity Disorder cause byEpigenetic action and gene environment interaction.
Project/Area Number |
23659341
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Public health/Health science
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Research Institution | Hokkaido University |
Principal Investigator |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
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Co-Investigator(Kenkyū-buntansha) |
AZUMI Kaoru 北海道大学, 環境健康科学研究教育センター, 特任講師 (90221720)
IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
YOSHIOKA Eiji 旭川医科大学, 医学部, 准教授 (70435957)
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Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Hideaki 北海道大学, 大学病院, 助教 (80374411)
SASAKI Seiko 北海道大学, 医学(系)研究科(研究院), 助教 (30448831)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 注意欠損 / 多動性障害(ADHD),環境要因,エピジェネティクス,喫煙,葉酸,環境遺伝相互作用 / 注意欠損・多動性障害(ADHD) / 環境要因 / エピジェネティクス / 喫煙 / 葉酸 / 環境遺伝交互作用 / 注意欠損・多動性障害(ADHD) |
Research Abstract |
In this study, for clarification of the effect of smoking on ADHD in 8-year old children, questionnaires containing Conners3 were used in a prospective cohort study. Questionnaires were filled by 1,192 cases with 8 years old. ADHD as outcome were considered as ‘attention- deficit’, ‘hyperactive impulsive’ and ‘comprehensive index’. Smoking of mothers before pregnancy and parents with children at the age of 7 years old, was higher in all of 3 mentioned ADHD categories (p=0.014~0.006). Using Conners3 criteria,8 cases of ADHD were compared to 28 cases as control group. Intelligence test by WISC-IV did not show any significant differences between both of groups. Factors related to ADHD development including environmental chemical exposure, metabolism-related geneticpolymorphism and genetic-environment interaction were summarized in a review article.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Effects of Maternal 5,10-Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphisms and Tobacco Smoking on Infant Birth Weight in a Japanese Population2012
Author(s)
Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R.
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Journal Title
Journal of Epidemiology
Volume: 22
Issue: 2
Pages: 91-102
DOI
NAID
ISSN
0917-5040, 1349-9092
Related Report
Peer Reviewed
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[Journal Article] A DYNC1H1 mutation causes a dominant spinal muscular atrophy with lower extremity.2012
Author(s)
Tsurusaki Y, Saitoh S, Tomizawa K, Sudo A, Asahina N, Shiraishi H, Ito J, Tanaka H, Doi H, Saitsu H, Miyake N, Matsumoto N.
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Journal Title
Neurogenetics.
Volume: 13
Issue: 4
Pages: 327-332
DOI
Related Report
Peer Reviewed
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[Journal Article] Cohort Profile : The Hokkaido Study on Environment and Children's Health in Japan2011
Author(s)
Kishi R, Sasaki S, Yoshioka E, Yuasa M, Sata F, Saijo Y, Kurahashi N, Tamaki J, Endo T Sengoku K, Nonomura K, Minakami H.
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Journal Title
Int J Epidemiol.
Volume: 40(3)
Issue: 3
Pages: 611-618
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of prenatal environmental tobacco smoke exposure on infant birth size2011
Author(s)
Braimoh TS, Sasaki S, Yila TA,Baba T, Miyashita C, Okada E,Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
Organizer
The American Public Health Association (APHA) 139th Annual Meeting and Exposition
Place of Presentation
Washington Convention Center,USA
Related Report
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[Presentation] Effects of prenatal environmental tobacco smoke exposure on infant birth size2001
Author(s)
Braimoh TS, Sasaki S, Yila TA,Baba T, Miyashita C, Okada E,Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
Organizer
The American Public Health Association (APHA)139th Annual Meeting and Exposition
Place of Presentation
Washington ConventionCenter,USA
Related Report
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