| Project/Area Number |
23659341
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Public health/Health science
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| Research Institution | Hokkaido University |
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Principal Investigator |
KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
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| Co-Investigator(Kenkyū-buntansha) |
AZUMI Kaoru 北海道大学, 環境健康科学研究教育センター, 特任講師 (90221720)
IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715)
YOSHIOKA Eiji 旭川医科大学, 医学部, 准教授 (70435957)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRAISHI Hideaki 北海道大学, 大学病院, 助教 (80374411)
SASAKI Seiko 北海道大学, 医学(系)研究科(研究院), 助教 (30448831)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 注意欠損 / 多動性障害(ADHD),環境要因,エピジェネティクス,喫煙,葉酸,環境遺伝相互作用 / 注意欠損・多動性障害（ADHD) / 環境要因 / エピジェネティクス / 喫煙 / 葉酸 / 環境遺伝交互作用 / 注意欠損・多動性障害（ADHD） |
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| Research Abstract |
In this study, for clarification of the effect of smoking on ADHD in 8-year old children, questionnaires containing Conners3 were used in a prospective cohort study. Questionnaires were filled by 1,192 cases with 8 years old. ADHD as outcome were considered as ‘attention- deficit’, ‘hyperactive impulsive’ and ‘comprehensive index’. Smoking of mothers before pregnancy and parents with children at the age of 7 years old, was higher in all of 3 mentioned ADHD categories (p=0.014~0.006). Using Conners3 criteria,8 cases of ADHD were compared to 28 cases as control group. Intelligence test by WISC-IV did not show any significant differences between both of groups. Factors related to ADHD development including environmental chemical exposure, metabolism-related geneticpolymorphism and genetic-environment interaction were summarized in a review article.
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