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Development of combination methods with dendritic cells and novel chemokine products for preventing hepatocellular carcinoma recurrence

Research Project

Project/Area Number 23659396
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionUniversity of Fukui

Principal Investigator

NAKAMOTO Yasunari  福井大学, 医学部, 教授 (40293352)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords癌 / 免疫学 / トランスレーショナルリサーチ / 動物 / 内科 / トランスレーショナルリサーチ
Research Abstract

The current study was designed to develop the combination methods with dendritic cells and novel chemokine products for preventing the recurrence of hepatocellular carcinoma following the treatments. The methods of dendritic cell induction were modified using OK-432 and zinc, and the chemokine products were evaluated for the activation of the cancer immunity. Furthermore, the biological stability of the products was improved by recombinant technology. Collectively, the results indicated that the modified methods using both dendritic cells and the chemokine products may contribute to the reduction of hepatocellular carcinoma recurrence.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results,  Open Access: 3 results) Presentation (8 results)

  • [Journal Article] Gd-EOB-DTPA-enhanced magnetic resonance imaging and alpha-fetoprotein predict prognosis of early-stage hepatocellular carcinoma.2014

    • Author(s)
      Yamashita T, Kitao A, Matsui O, Hayashi T, Nio K, Kondo M, Ohno N, Miyati T, Okada H, Yamashita T, Mizukoshi E, Honda M, Nakanuma Y, Takamura H, Ohta T, Nakamoto Y, Yamamoto M, Takayama T, Arii S, Wang XW, Kaneko S
    • Journal Title

      Hepatology

      Volume: in press Issue: 5 Pages: 1674-85

    • DOI

      10.1002/hep.27093

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multicenter validation study of anti-programmed cell death-1 antibody as a serological marker for type 1 autoimmune hepatitis2014

    • Author(s)
      Miyake Y, Yamamoto K, Matsushita H, Abe M, Takahashi A, Umemura T, Tanaka A, Nakamuta M, Nakamoto Y, Ueno Y, Saibara T, Takikawa H, Yoshizawa K, Ohira H, Zeniya M, Onji M, Tsubouchi H; Intractable Liver and Biliary Diseases Study Group of Japan
    • Journal Title

      Hepatol Res.

      Volume: 44 Issue: 13 Pages: 1299

    • DOI

      10.1111/hepr.12305

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vivo immunological antitumor effect of OK-432-stimulated dendritic cell transfer after radiofrequency ablation.2014

    • Author(s)
      Nakagawa H, Mizukoshi E, Iida N, Terashima T, Kitahara M, Marukawa Y, KitamuraK, Nakamoto Y, Hiroishi K, Imawari M, Kaneko S
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 63(4) Issue: 4 Pages: 347-356

    • DOI

      10.1007/s00262-013-1514-7

    • NAID

      120005368239

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathophysiological Decrease in the Regional Cerebral Blood Flow in Hashimoto's Encephalopathy : A Multiple-Case SPECT Study2014

    • Author(s)
      Muramatsu T, Ikawa M, Yoneda M, Sugimoto K, Matsunaga A, Yamamura O, Hamano T, Okazawa H, Nakamoto Y
    • Journal Title

      Eur Neurol

      Volume: 72 Pages: 13-19

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/24777056

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma.2013

    • Author(s)
      Yamashita T, Nakamoto Y, et al.
    • Journal Title

      Hepatology

      Volume: 57 Issue: 4 Pages: 1484-1497

    • DOI

      10.1002/hep.26168

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis.2013

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Journal Title

      Cancer Immunol Immunother.

      Volume: 62(8) Issue: 8 Pages: 1421-1430

    • DOI

      10.1007/s00262-013-1447-1

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Correction : TNF-α and Tumor Lysate Promote the Maturation of Dendritic Cells for Immunotherapy for Advanced Malignant Bone and Soft Tissue Tumors2013

    • Author(s)
      Miwa S, Nishida H, Tanzawa Y, Takata M, Takeuchi A, Yamamoto N, Shirai T, Hayashi K, Kimura H, Igarashi K, Mizukoshi E, Nakamoto Y, Kaneko S, Tsuchiya H
    • Journal Title

      PLoS One (eCollection 2013.)

      Volume: 24 Pages: 8-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of preclinically latent hyperperfusion due to stroke-like episodes by arterial spin-labeling perfusion MRI in MELAS patients.2013

    • Author(s)
      Masamichi Ikawa, Makoto Yoneda, Tomoko Muramatsu, Akiko Matsunaga, Tetsuya Tsujikawa, Tatsuya Yamamoto, Nobuyuki Kosaka, Kazuyuki Kinoshita, Osamu Yamamura, Tadanori Hamano, Yasunari Nakamoto, Hirohiko Kimura
    • Journal Title

      Mitochondrion

      Volume: 13(6) Issue: 6 Pages: 676-680

    • DOI

      10.1016/j.mito.2013.09.007

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hashimoto's encephalopathy as a treatable adult-onset cerebellar ataxia mimicking spinocerebellar degeneration2013

    • Author(s)
      Matsunaga A, Ikawa M, Fujii A, Nakamoto Y, Kuriyama M, Yoneda M
    • Journal Title

      Eur. Neurol

      Volume: 69 Issue: 1 Pages: 14-20

    • DOI

      10.1159/000342217

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNF-α and tumor lysate promote the maturation of dendritic cells for immunotherapy for advanced malignant bone and soft tissue tumors2012

    • Author(s)
      Miwa S, Tsuchiya H, et al
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 12 Pages: e52926-e52926

    • DOI

      10.1371/journal.pone.0052926

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical relevance and sequence analysis of the Helicobacter pylori dupA region from two areas in Japan with different gastric cancer risks2012

    • Author(s)
      Matsuda H, Ito Y, Suto H, Yamakawa A, Satomi S, Ohtani M Yamazaki Y, Kusaka Y, Shimabukuro Y, Kikuchi K, Keida Y, Azuma T, Nakamoto Y
    • Journal Title

      Immuno-Gatroenterology

      Volume: 1:2 Pages: 127-135

    • URL

      http://www.stmconnect.com/ig

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Membrane-bound form of monocyte chemoattractant protein-1 enhances antitumor effects of suicide gene therapy in a model of hepatocellular carcinoma.2012

    • Author(s)
      Marukawa Y
    • Journal Title

      Cancer Gene Ther.

      Volume: 19(5) Issue: 5 Pages: 312-319

    • DOI

      10.1038/cgt.2012.3

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Nucleostemin in injury-induced liver regeneration.2012

    • Author(s)
      Shugo. H
    • Journal Title

      Stem cells Dev.

      Volume: 21 Issue: 16 Pages: 3044-3054

    • DOI

      10.1089/scd.2011.0725

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guideline on the use of new anticancer drugs for the treatment of Hepatocellular Carcinoma 2010 update2012

    • Author(s)
      Kaneko S, Furuse J, Kudo M, Ikeda K, Honda M, Nakamoto Y, Onchi M, Shiota G, Yokosuka O, Sakaida I, Takehara T, Ueno Y, Hiroishi K, Nishiguchi S, Moriwaki H, Yamamoto K, Sata M, Obi S, Miyayama S, Imai Y
    • Journal Title

      Hepatol. Res

      Volume: 42 Issue: 6 Pages: 523

    • DOI

      10.1111/j.1872-034x.2012.00981.x

    • NAID

      10031144267

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of systemic redox states in patients carrying MELAS A3243G mutation in mitochondrial DNA.2012

    • Author(s)
      Masamichi Ikawa, Kenichiro Arakawa, Tadanori Hamano, Miwako Nagata, Yasunari Nakamoto, Masaru Kuriyama, Yasutoshi Koga, Makoto Yoneda.
    • Journal Title

      European Neurology

      Volume: 67(4) Issue: 4 Pages: 232-7

    • DOI

      10.1159/000336568

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization2011

    • Author(s)
      Nakamoto Y, Mizukoshi E, Kitahara M, Arihara F, Sakai Y, Kakinoki K, Fujita Y, Marukawa Y, Arai K, Yamashita T, Mukaida N, Matsushima K, Matsui O, and Kaneko S
    • Journal Title

      Clin Exp Immunol

      Volume: 163(2) Issue: 2 Pages: 165-177

    • DOI

      10.1111/j.1365-2249.2010.04246.x

    • NAID

      120003141443

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma2011

    • Author(s)
      Honda M, (他9名, 9番目)
    • Journal Title

      Hepatology

      Volume: 53(4) Issue: 4 Pages: 206-16

    • DOI

      10.1002/hep.24149

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma2011

    • Author(s)
      Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
    • Journal Title

      Cancer Lett

      Volume: 307 Issue: 2 Pages: 165-173

    • DOI

      10.1016/j.canlet.2011.03.029

    • NAID

      120003141809

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Malnutrition Impairs Interferon Signaling Through mTOR and FoxO Pathways in Patients With Chronic Hepatitis C2011

    • Author(s)
      Honda M, 他19名
    • Journal Title

      Gastroenterology

      Volume: 141(1) Issue: 1 Pages: 128-40

    • DOI

      10.1053/j.gastro.2011.03.051

    • NAID

      40019193331

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellularcar cinoma2011

    • Author(s)
      Honda M, (他10名, 10番目)
    • Journal Title

      Oncology

      Volume: 81(5-6) Issue: 5-6 Pages: 281-90

    • DOI

      10.1159/000334439

    • NAID

      120003674297

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequency of CD45RO(+) subset in CD4(+)CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma.2011

    • Author(s)
      Takata Y, Nakamoto Y, et al.
    • Journal Title

      Cancer Lett.

      Volume: 307 Pages: 165-173

    • NAID

      120003141809

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Clinical evaluation of patency capsule system in high risk patients for video capsule endoscopy2013

    • Author(s)
      Ohtani M, Suto H, Nakamoto Y
    • Organizer
      Japan Digestive DiseaseWeek 2013
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B2012

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, Hepatology 56 (4,Suppl.) 315A
    • Year and Date
      2012-11-13
    • Related Report
      2013 Final Research Report
  • [Presentation] High Incidence of HBV Reactivation after R-CHOP and CHOP Regimens among Patients Treated with Six Immunosuppressive Chemotherapies2012

    • Author(s)
      Naito T, Nemoto T, Matsuda H, Ohtani M, Suto H Nakamoto Y
    • Organizer
      第63回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, Hepatology 56 (4,Suppl.) 643A
    • Year and Date
      2012-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, Hepatology 54 (4,Suppl.) 1300A
    • Year and Date
      2011-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact for prognosis of patients2011

    • Author(s)
      Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California, Hepatology 54 (4,Suppl.) 1400A
    • Year and Date
      2011-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Differential Dynamics of the NF-kappaB subunits RELA and RELB in a Mouse Model of Chronic Hepatitis B.2011

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第62回American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      San Francisco, California
    • Related Report
      2011 Research-status Report
  • [Presentation] Clinical evaluation of patency capsule system in high risk patients for video capsule endoscopy.

    • Author(s)
      Ohtani M, Suto H, Nakamoto Y
    • Organizer
      Japan Digestive Disease Week 2013
    • Place of Presentation
      Grand Prince Hotel New Takanawa, Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] MicroRNA Dynamics in Precancerous Lesions in a Mouse Model of Chronic Hepatitis B.

    • Author(s)
      Nakamoto Y, Yamashita T, Kaneko S
    • Organizer
      第63回 American Association for the Study of Liver Diseases (AASLD) Annual Meeting
    • Place of Presentation
      Boston, Massachusetts, U.S.A.
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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