| Project/Area Number |
23659401
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ARIMURA Yoshiaki 札幌医科大学, 医学部, 講師 (80305218)
FUJIMIYA Mineko 札幌医科大学, 医学部, 教授 (10199359)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | fresh cadaver / 骨髄間葉系幹細胞(MSC) / AOM (azoxymethane) / 骨髄間葉系幹細胞（MSC） / 早期献体（fresh cadaver） / azoxymethane（AOM） / chemoprevention / 炎症発癌 / WNTシグナル |
|---|
| Research Abstract |
The purposes of the study were to elucidate a role of MSC on inflammatory carcinogenesis and to conductpreclinical studies according to GLP. MSC reducedO6MeG adducts and colonic epithelial cells escaped from acute apoptotic response of genotoxic azoxymethane(AOM) finally induced G1 arrest on the cell cycle or apoptosis, which resulted in partially cancel AOM-induced tumor initiation. In the two of nine fresh cadavers, MSCs derived from cadavers could cultivate up to three passages. It is necessary to establish more efficacious isolation and cultivation methods from cadavers’ MSCs.
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