Challenging research for elucidating the role of oral bacteria in the pathogenesis of IBD

• Project/Area Number: 23659402
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Yokohama City University
• Principal Investigator: NAKAJIMA Atsushi 横浜市立大学, 附属病院, 教授 (30326037)
• Co-Investigator(Kenkyū-buntansha): WADA Koichiro 大阪大学, 歯学研究科, 准教授 (90263467)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 炎症性腸疾患 / 齲蝕菌 / 医学 / 口腔内細菌

Research Abstract

The pathogenesis of Inflammatory Bowel Disease (IBD) is still unknown. Caries bacteria, Streptococcus mutans (S. mutans) is known to cause the systemic disease such as endocarditis or sepsis. We have recently found that special types of S. mutans had tendency cause the systemic disease. In this research, we elucidate the role of S. mutans in the pathogenesis of the IBD using animal model and patients samples, and evaluate the risk for the developing the IBD.

Research Products

• [Journal Article] Role of leukotriene B_4 receptor signaling in human preadipocyte differentiation. (2012)
  • Author(s): Hirata K, Katayama K, Nakajima A, Takada K, Kamisaki Y, Wada K
  • Journal Title: Biochem Biophys Res Commun Volume: 429(3-4) Issue: 3-4 Pages: 197-203
  • DOI: 10.1016/j.bbrc.2012.10.110
  • Peer Reviewed
• [Journal Article] Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling (2012)
  • Author(s): Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, Kato S, Mawatari H, Shibata W, Kitani H, Ikejima K, Kirikoshi H, Nakajima N, Saito S, Maeyama S, Watanabe S, Wada K, Nakajima A
  • Journal Title: Cell Metab Volume: 16(1) Issue: 1 Pages: 44-54
  • DOI: 10.1016/j.cmet.2012.05.012
  • Peer Reviewed
• [Journal Article] Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis (2012)
  • Author(s): Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T.
  • Journal Title: Scientific Reports Volume: 2 Issue: 1 Pages: 332-332
  • DOI: 10.1038/srep00332
  • Peer Reviewed
• [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease (2012)
  • Author(s): Yoneda M, Naka S, Nakano K, Wada K, Endo H, Mawatari H, Imajo K, Nomura R, Hokamura K, Ono M, Murata S, Tohnai I, Sumida Y, Shima T, Kuboniwa M, Umemura K, Kamisaki Y, Amano A, Okanoue T, Ooshima T, Nakajima A.
  • Journal Title: BMC Gastroenterol Volume: 12 Issue: 1 Pages: 12-16
  • DOI: 10.1186/1471-230x-12-16
  • Peer Reviewed
• [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke (2011)
  • Author(s): Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.
  • Journal Title: Nature Communications Volume: 2 Issue: 1 Pages: 485-485
  • DOI: 10.1038/ncomms1491
  • Peer Reviewed
• [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis (2011)
  • Author(s): Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T
  • Journal Title: Oral Diseases Volume: 17(4) Issue: 4 Pages: 370-378
  • DOI: 10.1111/j.1601-0825.2010.01759.x
  • Peer Reviewed
• [Journal Article] 非アルコール性脂肪肝炎発症のリスクファクターとしての口腔細菌(総説) (2011)
  • Author(s): 和田孝一郎, 上崎善規, 中島淳
  • Journal Title: 臨床薬理 Volume: 42 Pages: 67-68
• [Presentation] Oral bacteria-induced serious systemic diseases: "Stroke" and "Cardiovascular disease" up-to-date (2012)
  • Author(s): Wada K. Nakajima A, Kamisaki Y
  • Organizer: Invited educational lecture at URAD Research Center
  • Place of Presentation: Shanghai University of T.C.M , Shanghai. China.
  • Year and Date: 2012-05-13
• [Presentation] Periodontal pathogen, Porphyromonas gingivalis is a potential risk factor for nonalcoholic fatty liver disease (2012)
  • Author(s): Wada K, Yoneda M, Kamisaki Y, Nakajima A
  • Organizer: The 85th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: (京都国際会議場)Kyoto
• [Presentation] The collagen-binding protein of Streptococcus mutans is involved in hemorrhage (2012)
  • Author(s): Hokamura K, Wada K, Nakano K, Min T, Ooshima T, Umemura K
  • Organizer: The 85th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: (京都国際会議場)Kyoto
• [Presentation] Serotype k Streptococcus mutans strains with collagen-binding properties aggravates inflammatory bowel diseases (2012)
  • Author(s): Kojima A, Wada K, Nakano K, Ooshima T, Umemura K, Nakajima A, Kamisaki Y
  • Organizer: The 85th Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: (京都国際会議場)Kyoto
• [Remarks] (1)ホームページ等
  • URL: http://www-user.yokohama-cu.ac.jp/~nai3syou/
• [Remarks] 1.虫歯菌感染で大腸炎リスク4倍 阪大など解明: 日本経済新聞 2012年3月26日、ほか、新聞多数
• [Remarks] 2. 和田孝一郎、日暮琢磨。ミュータンス菌: 脳出血と潰瘍性大腸炎にも関与。日経メディカル 2012年 5 月