| Project/Area Number |
23659406
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
YAMAGUCHI Taketo 千葉県がんセンター(研究所), その他部局等, 副病院長 (00241969)
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| Co-Investigator(Kenkyū-buntansha) |
住本 秀敏 帝京大学, 医学部, 講師 (00306838)
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| Co-Investigator(Renkei-kenkyūsha) |
伊丹 真紀子 (20539150)
横井 左奈 (30372452)
大平 美紀 (20311384)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | MALT / 胃 / リンパ腫 / 免疫 / ヘリコバクター・ピロリ / 胃MALT / H. pylori / 除菌 / 寛解 / RNA発現解析 / Foxp3 / CD4 |
|---|
| Research Abstract |
Gastric MALT lymphoma is frequently accompanied by chronic infection with Helicobacter pylori (HP) in the gastric mucosa. Although most of MALT lymphoma could be cured following the eradication of HP, the mechanism has remained to be elucidated. HP protects itself from the surrounding immune system by suppressing the immune cells, making the persistence of the infection possible. On the other hand, many malignancies create immune-suppressive microenvironments for the evasion from the immune system. We focused on the similarities of these diseases. We evaluated the immune responses in the tumor following HP eradication, and found the number of regulatory T cells, which are major immune-suppressive effector cells, were decreased, which was correlated to the cure of the lymphoma. Our results suggest the amelioration of the immune-suppressive microenvironment is the possible mechanism for the cure of MALT lymphoma following HP eradication.
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