| Project/Area Number |
23659435
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
INOUE Hiromasa 鹿児島大学, 大学院・医歯学総合研究科, 教授 (30264039)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masaki 鹿児島大学, 大学院・医歯学総合研究科, 特任助教 (90398298)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MURAKAMI Makoto 東京都医学総合研究所, 脂質代謝プロジェクト, プロジェクトリーダー (60276607)
OIKE Yuichi 熊本大学, 大学院・医学薬学研究部, 教授 (90312321)
|
|---|
| Research Collaborator |
KUBOTA Shingo 鹿児島大学, 大学院・医歯学総合研究科, 大学院生
SADAMURA Yukari 鹿児島大学, 大学院・医歯学総合研究科, 大学院生
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 難治性呼吸器疾患 / 気管支喘息 / 肺線維症 / 抗体療法 |
|---|
| Research Abstract |
Severe asthma and idiopathic pulmonary fibrosis are chronic lung diseases of notable unmet medical need. Focusing on secretory phospholipase A2 and angiopoietin-like proteins, we studied here the mechanisms underlying allergic asthma and lung fibrosis to find new therapeutic targets with novel antibody therapy. Deficiency of a group of secretory phospholipase A2 augmented asthma phenotypes in a mouse model. Expression of a member of angiopoietin-like proteins was increased in the lung tissues from a mouse model of lung fibrosis and from the patients with pulmonary fibrosis. We also found that vascular endothelial growth factor (VEGF) plays an important role in pathogenesis of lung fibrosis in mice, and our findings suggest that the genetic delivery of monoclonal anti-VEGF antibodyis a novel alternative to conventional monoclonal antibody therapy.
|
