| Project/Area Number |
23659451
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
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| Keywords | 神経分子病態学 / vCJD / プリオン / ウシ型ノックインマウス / FDC |
|---|
| Research Abstract |
We revealed that bovinized knock-in mice were successfully infected with the agent from knock-in mice with codon 129V/V inoculated with variant Creutzfedlt-jakob disease as well as that from Humanized knock-in mice with codon 129M/M inoculated with variant Creutzfedlt-jakob disease, that from humanized knock-in mice with codon 129M/V inoculated with variant Creutzfedlt-jakob disease, and that from variant Creutzfedlt-jakob disease patients. It provides a new opportunity to re-analyze sporadic Creutzfedlt-jakob disease patients with the 129V/V genotype in countries with bovine spongiform encephalopathy and variant Creutzfedlt-jakob disease, particularly in cases with atypical clinical and neuropathological features.
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