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Pathophysiology of myelodyspoastic syndrome - network between bone marrow and nervus system

Research Project

Project/Area Number 23659482
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionUniversity of Tsukuba

Principal Investigator

CHIBA Shigeru  筑波大学, 医学医療系, 教授 (60212049)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsネスチン / 骨髄異形成症候群 / 骨髄異形性症候群 / Nestin / 癌 / 細胞・組織
Research Abstract

In normal human bone marrow, spindle-shaped nestin-expressing cells, distinct from endothelial cells, were shown as the vascular vessel wall-constituting cells. In contrast, such a structure was disarranged in the bone marrow of myelodyspoastic syndrome patients. We further found abnormalities in fetal liver hematopoiesis in mice with knocked-down Notch signaling in cells expressing nestin, implying important roles of Notch signaling in nestin-expressing stromal cells in hematopoiesis.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (31 results)

All 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (12 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis.2012

    • Author(s)
      Yuhei Kamada
    • Journal Title

      Int J Hematol

      Volume: 96 Issue: 4 Pages: 492-500

    • DOI

      10.1007/s12185-012-1171-1

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 and Immune Function.2012

    • Author(s)
      Mamiko Sakata-Yanagimoto
    • Journal Title

      Curr Top Microbiol Immunol

      Volume: 360 Pages: 151-161

    • DOI

      10.1007/82_2012_235

    • ISBN
      9783642242939, 9783642242946
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes2012

    • Author(s)
      Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H
    • Journal Title

      Arthritis Research and Ttherapy

      Volume: Vol.14 Issue: 2

    • DOI

      10.1186/ar3758

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch2 regulates the development of marginal zone B cells through Fos2012

    • Author(s)
      Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoka K, Chiba S, Shimada M, Yasutomo K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 418 Pages: 701-707

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin2012

    • Author(s)
      Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
    • Journal Title

      Oncogene

      Volume: 31 Pages: 787-798

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol: a single center retrospective analysis.2011

    • Author(s)
      Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
    • Journal Title

      J Clin Exp Hematopathol

      Volume: 51 Pages: 109-114

    • NAID

      10030207641

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia2011

    • Author(s)
      Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki
    • Journal Title

      Nature

      Volume: 478(7367) Pages: 64-69

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver2011

    • Author(s)
      Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, Takahashi S
    • Journal Title

      Blood

      Volume: 118 Pages: 1374-1385

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The LRF transcription factor regulates mature B cell development and the germinal center response in mice2011

    • Author(s)
      Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T.
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 2583-2598

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Treatment Outcome of Adult Burkitt Lymphoma in Japanese Patients with Modified LMB Protocol : A Single Center Retrospective Analysis2011

    • Author(s)
      Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
    • Journal Title

      Journal of Clinical and Experimental Hematopathology

      Volume: 51 Issue: 2 Pages: 109-114

    • DOI

      10.3960/jslrt.51.109

    • NAID

      10030207641

    • ISSN
      1346-4280, 1880-9952
    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia2011

    • Author(s)
      Kenichi Yoshida
    • Journal Title

      Nature

      Volume: 478 Issue: 7367 Pages: 64-69

    • DOI

      10.1038/nature10496

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Notch-dependent and -independent regulation of mature B cell lineage fate and humoral immune response by the LRF transcription factor homodimer2011

    • Author(s)
      Nagisa Sakurai
    • Journal Title

      Journal of Clinical Investigation

      Volume: 121 Issue: 7 Pages: 2583-2598

    • DOI

      10.1172/jci45682

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria2011

    • Author(s)
      Yukinori Kozuma
    • Journal Title

      British Journal of Haematology

      Volume: 152 Issue: 5 Pages: 631-639

    • DOI

      10.1111/j.1365-2141.2010.08505.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] First-Line Treatment and Outcome of Elderly Patients with Primary Central Nervous System Lymphoma (PCNSL) - A Systematic Review and Individual Patient Data Meta-Analysis2012

    • Author(s)
      Benjamin Kasenda
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Recurrent Mutations of Multiple Components of Cohesin Complex in Myeloid Neoplasms.2012

    • Author(s)
      Ayana Kon
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition.
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Soluble Recombinant Thrombomodulin Is a Potentially Promising Agent without Causing Severe Hemorrhagic Events for Hematological Malignancy-Induced Disseminated Intravascular Coagulation2012

    • Author(s)
      Naoki Kurita
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Implication of the Distinct Differentiation Pathway of Megakaryocytes From Hematopoietic Stem Cells in the Mouse Bone Marrow2012

    • Author(s)
      Hidekazu Nishikii
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition.
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Transcription Factor Hes1 Functions As a Tumor Suppressor in MLL-Associated Acute Leukemia2012

    • Author(s)
      Takayasu Kato
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition.
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Reduced Tet2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice2012

    • Author(s)
      Hideharu Muto
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition.
    • Place of Presentation
      Georgia World Congress Center. Atlanta, USA
    • Year and Date
      2012-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] Detection of PNH-type cells using high-resolution flow cytometry: Interim analysis of OPTIMA study2012

    • Author(s)
      Kohei Hosokawa
    • Organizer
      第74回日本血液学会学術集会.
    • Place of Presentation
      京都京都国際会議場
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Spectrum of gene mutations in myelodysplastic syndromes revealed by whole-exome sequencing2012

    • Author(s)
      Kenichi Yoshida
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都国際会議場. 京都
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] TET2 regulates erythropoiesis from human cord blood progenitors2012

    • Author(s)
      榎並 輝和
    • Organizer
      第74回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reduced Tet2 Function Contributes to Development of Peripheral T-Cell Lymphoma with Follicular Helper T-Cell-Like Features in Mice2012

    • Author(s)
      武藤 秀治
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition
    • Place of Presentation
      Altanta, GA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Implication of the Distinct Differentiation Pathway of Megakaryocytes From Hematopoietic Stem Cells in the Mouse Bone Marrow2012

    • Author(s)
      錦井 秀和
    • Organizer
      The American Society of Hematology 54th Annual Meeting and Exposition
    • Place of Presentation
      Altanta, GA, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 国際的な臍帯血バンクネットワークを基盤とした臍帯血のやり取り2012

    • Author(s)
      栗田尚樹, Francesco Frassoni, Nicoletta Sacchi, Claudia Cossu, Alberto Serio, Canieda Cilloni, 千葉滋, Maria Podesta
    • Organizer
      第34回日本造血幹細胞移植学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Book] Medical Practice「実地医家のための臨床検査のすすめかた・評価のしかた2012

    • Author(s)
      小原直
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 最新医学別冊2011

    • Author(s)
      千葉滋
    • Publisher
      最新医学社
    • Related Report
      2012 Final Research Report
  • [Book] Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Base Regenerative Medicine2011

    • Author(s)
      Craig S. Atwood
    • Total Pages
      410
    • Publisher
      INTECH (Viena)
    • Related Report
      2011 Research-status Report
  • [Book] 造血幹細胞移植の基礎と臨床(改訂版)2010

    • Author(s)
      錦井秀和
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.ketsunai.com

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/hematology/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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