Analysis of pathogenesis of juvenile myelomonocytic leukemia and establishment of its treatment using disease-specific iPS cells
| Project/Area Number |
23659514
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ETO Kouji 京都大学, iPS細胞研究所, 教授 (50286986)
MOCHIZUKI Shinji 東京大学, 医科学研究所, 特任助教 (90349473)
|
|---|
| Project Period (FY) |
2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
|
|---|
| Keywords | 若年性骨髄単球性白血病 / iPS細胞 / 1型神経線維腫症 / NF1 / 1型神経繊維腫症 |
|---|
| Research Abstract |
To clarify the mechanisms in which the continuous activation of GM-CSF receptor-RAS pathway induces juvenile myelomonocytoc leukemia(JMML), we tried to establish induced pluripotent stem cells derived from patients with type 1 neurofibromatosis(NF1-iPS cells) possessing a heterozygous mutation of NF1. However, NF1-iPS cells were not established in spite of several times of transduction experiments., We are now using Sendai virus vectors for the transduction of various reprogramming factors into somatic cells of NF1 patients, but our result may suggest a possibility that NF1 mutation may suppress the nuclear reprogramming.
|
Report
(2 results)
Research Products
(74 results)
-
-
[Journal Article] Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells2012
Author(s)
Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T
-
Journal Title
Blood
Volume: 119(1)
Issue: 1
Pages: 83-94
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
[Journal Article] Heterozygous ITGA2B R995W mutation inducing constitutive activation of the {alpha}IIb{beta}3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia2011
Author(s)
Kunishima S, Kashiwagi H, Otsu M, Takayama N, Eto K, Onodera M, Miyajima Y, Takamatsu Y, Suzumiya J, Matsubara K, Tomiyama Y, Saito H
-
Journal Title
Blood
Volume: 117
Issue: 20
Pages: 5479-5484
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
