| Project/Area Number |
23659549
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Mie University |
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Principal Investigator |
KAWANO Mitsuo 三重大学, 大学院・医学系研究科, 講師 (00234097)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANAKA Keiichi 三重大学, 医学系研究科, 准教授 (70314135)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚腫瘍学 / PIV2 / メラノーマ / 遺伝子免疫療法 / 腫瘍免疫 / 免疫活性化 / 細胞性免疫 / 液性免疫 / 生体制御 |
|---|
| Research Abstract |
To establish a novel genetic immunotherapy instead of conventional chemotherapy and radiotherapy against refractory malignant melanoma, we have developed the parainfluenza type 2 virus vector introduced TRP-2 gene known as melanoma differentiation antigen or Ag85B gene inducing strong Th1 adjuvant activity. We analyzed the antitumor effect and the immune mechanisms by intranasal administrationto melanoma like model mice using the next generation spray vaccine for melanoma.
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