Prevention of neuropsychiatric functional disease

• Project/Area Number: 23659564
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Mie University
• Principal Investigator: OKADA Motohiro 三重大学, 大学院・医学系研究科, 教授 (10281916)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 精神薬理学 / 機能性疾患 / 情報伝達

Research Abstract

To explore the pathogenesis of autosomal dominant nocturnal frontal lobe epilepsy and to develop novel antiepileptic drug, the present study develop the S286L transgenic rats. The validations of S286L transgenic rats were demonstrated by several examinations. However, after onset epilepsy in S286L transgenic rat, prevention of expression of S286L mutant Chrna4 could not affect the phenotypes of S284L transgenic rats.

Research Products

• [Journal Article] ONO-2506 inhibits spike-wave discharges in a genetic animal model without affecting traditional convulsive tests via gliotransmission regulation (2013)
  • Author(s): Yamamura, S., Hoshikawa, M., Kato, D., Saito, H., Suzuki, N., Niwa, O., Okada, M.
  • Journal Title: Br J Pharmacol Volume: 168 Pages: 1088-1100
  • Peer Reviewed
• [Journal Article] Differential mechanisms underlie the regulation of serotonergic transmission in the dorsal and median raphe nuclei by mirtazapine: a dual probe microdialysis study (2013)
  • Author(s): Fukuyama, K., Tanahashi, T., Hamaguchi, T., Nakagawa, M., Shiroyama, T., Motomura, E., Okada, M
  • Journal Title: Psychopharmacology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Levetiracetam inhibits neurotransmitter release associated with CICR (2012)
  • Author(s): Fukuyama, K., Tanahashi, S., Nakagawa, M., Yamamura, S., Motomura, E., Shiroyama, T., Tanii, H., Okada, M
  • Journal Title: Neurosci Lett Volume: 518 Pages: 69-74
  • Peer Reviewed
• [Journal Article] The development of agoraphobia is associated with the symptoms and location of a patient's first panic attack (2012)
  • Author(s): Hara, N., Nishimura, Y., Yokoyama, C., Inoue, K., Nishida, A., Tanii, H., Okada, M., Kaiya, H., Okazaki, Y.
  • Journal Title: Biopsychosoc Med Volume: 6 Pages: 12-12
  • Peer Reviewed
• [Journal Article] Electroencephalographic dipole source modeling of frontal intermittent rhythmic delta activity (2012)
  • Author(s): Motomura, E., Inui, K., Ohoyama, K., Nishimura, Y., Nakagawa, M., Maeda, M., Matsushima, N., Ushiro, K., Suzuki, D., Kakigi, R., Okada, M
  • Journal Title: Neuropsychobiology Volume: 65 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Lamotrigine-induced neuroleptic malignant syndrome under risperidone treatment: a case report (2012)
  • Author(s): Motomura, E., Tanii, H., Usami, A., Ohoyama, K., Nakagawa, M., Okada, M.
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 24
  • Peer Reviewed
• [Journal Article] Combination Therapy of Zonisamide With Aripiprazole on ECTand Benzodiazepine-Resistant Periodic Catatonia (2012)
  • Author(s): Nakagawa, M., Yamamura, S., Motomura, E., Tanii, H., Okada, M
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 24
  • Peer Reviewed
• [Journal Article] Memory-based pre-attentive auditory N1 elicited by sound movement (2012)
  • Author(s): Ohoyama, K., Motomura, E., Inui, K., Nishihara, M., Otsuru, N., Oi, M., Kakigi, R., Okada, M
  • Journal Title: Neurosci Res Volume: 73 Pages: 248-251
  • Peer Reviewed
• [Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease (2012)
  • Author(s): Saito, Y., Inoue, T., Zhu, G., Kimura, N., Okada, M., Nishimura, M., Kimura, N., Murayama, S., Kaneko, S., Shigemoto, R., Imoto, K., Suzuki, T
  • Journal Title: Mol Neurodegeneration Volume: 7
  • Peer Reviewed
• [Journal Article] Novel delta1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex (2012)
  • Author(s): Tanahashi, S., Ueda, Y., Nakajima, A., Yamamura, S., Nagase, H., Okada, M
  • Journal Title: Neuropharmacology Volume: 62 Pages: 2057-2067
  • Peer Reviewed
• [Journal Article] Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus (2012)
  • Author(s): Tanahashi, S., Yamamura, S., Nakagawa, M., Motomura, E., Okada, M
  • Journal Title: Psychopharmacology (Berl) Volume: 220 Pages: 599-610
  • Peer Reviewed
• [Journal Article] Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission (2012)
  • Author(s): Tanahashi, S., Yamamura, S., Nakagawa, M., Motomura, E., Okada, M.
  • Journal Title: Neuropharmacology Volume: 62 Pages: 765-774
  • Peer Reviewed
• [Journal Article] Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes (2012)
  • Author(s): 765-774
  • Journal Title: Br J Pharmacol Volume: 165 Pages: 1543-1555
  • Peer Reviewed
• [Journal Article] Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype (2012)
  • Author(s): Zhu, G., Yoshida, S., Migita, K., Yamada, J., Mori, F., Tomiyama, M., Wakabayashi,K., Kanematsu, T., Hirata, M., Kaneko, S., Ueno, S., Okada, M
  • Journal Title: J Pharmacol Exp Ther Volume: 340 Pages: 520-528
  • Peer Reviewed
• [Journal Article] Source localization of posterior slow waves of youth using dipole modeling. (2012)
  • Author(s): Ohoyama K,
  • Journal Title: Psychiatry Clin Neurosci Volume: 66 Issue: 7 Pages: 582-586
  • DOI: 10.1111/j.1440-1819.2012.02398.x
  • Peer Reviewed
• [Journal Article] Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes (2012)
  • Author(s): Tanahashi, S., Yamamura, S., Nakagawa, M., Motomura, E., Okada, M.
  • Journal Title: Br J Pharmacol Volume: 165 Issue: 5 Pages: 1543-1555
  • DOI: 10.1111/j.1476-5381.2011.01638.x
  • Peer Reviewed
• [Journal Article] Dopamine D2 and serotonin 5-HT1A receptors mediate the actions of aripiprazole in mesocortical and mesoaccumbens transmission (2012)
  • Author(s): Tanahashi, S., Yamamura, S., Nakagawa, M., Motomura, E., Okada, M
  • Journal Title: Neuropharmacology Volume: 62 Issue: 2 Pages: 765-774
  • DOI: 10.1016/j.neuropharm.2011.08.031
  • Peer Reviewed
• [Journal Article] Novel delta1-receptor agonist KNT-127 increases the release of dopamine and L-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex (2012)
  • Author(s): Tanahashi, S., Ueda, Y., Nakajima, A., Yamamura, S., Nagase, H., Okada, M.
  • Journal Title: Neuropharmacology Volume: 62 Issue: 5-6 Pages: 2057-2067
  • DOI: 10.1016/j.neuropharm.2012.01.005
  • Peer Reviewed
• [Journal Article] Effect of lamotrigine and carbamazepine on corticotropin-releasing factor-associated serotonergic transmission in rat dorsal raphe nucleus (2012)
  • Author(s): Tanahashi, S., Yamamura, S., Nakagawa, M., Motomura, E., Okada, M.
  • Journal Title: Psychopharmacology (Berl) Volume: 220 Issue: 3 Pages: 599-610
  • DOI: 10.1007/s00213-011-2506-y
  • Peer Reviewed
• [Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease (2012)
  • Author(s): Saito Y
  • Journal Title: Mol Neurodegener Volume: 7 Issue: 1 Pages: 50-50
  • DOI: 10.1186/1750-1326-7-50
  • Peer Reviewed
• [Journal Article] Combination Therapy of Zonisamide With Aripiprazole on ECT- and Benzodiazepine-Resistant Periodic Catatonia. (2012)
  • Author(s): Nakagawa M
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 24 Issue: 3 Pages: 154-152
  • DOI: 10.1176/appi.neuropsych.11080191
  • Peer Reviewed
• [Journal Article] Lamotrigine-induced neuroleptic malignant syndrome under risperidone treatment : a case report (2012)
  • Author(s): Motomura, E., Tanii, H., Usami, A., Ohoyama, K., Nakagawa, M., Okada, M.
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 24 Issue: 2 Pages: 38-39
  • DOI: 10.1176/appi.neuropsych.11040093
  • Peer Reviewed
• [Journal Article] Memory-based pre-attentive auditory N1 elicited by sound movement (2012)
  • Author(s): Ohoyama, K., Motomura, E., Inui, K., Nishihara, M., Otsuru, N., Oi, M., Kakigi, R., Okada, M.
  • Journal Title: Neurosci Res Volume: 73 Issue: 3 Pages: 248-251
  • DOI: 10.1016/j.neures.2012.04.003
  • Peer Reviewed
• [Journal Article] Novel δ1-receptor agonist KNT-127 increases the release of dopamine and l-glutamate in the striatum, nucleus accumbens and median pre-frontal cortex. (2012)
  • Author(s): Tanahashi S, Okada M
  • Journal Title: Neuropharmacology Volume: 62 Pages: 2057-2067
  • Peer Reviewed
• [Journal Article] Dysfunction of extrasynaptic GABAergic transmission in phospholipase C-related, but catalytically inactive protein 1 knockout mice is associated with an epilepsy phenotype. (2012)
  • Author(s): Tanahashi S, Okada M.
  • Journal Title: J Pharmacol Exp Ther. Volume: 340 Pages: 520-528
  • Peer Reviewed
• [Journal Article] Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions. (2012)
  • Author(s): Yamamura S, Okada M.
  • Journal Title: Neuropharmacology Volume: 62 Pages: 550-560
  • Peer Reviewed
• [Journal Article] Effect of novel atypical antipsychotic, blonanserin, on extracellular neurotransmitter level in rat prefrontal cortex (2011)
  • Author(s): Ohoyama, K., Yamamura, S., Hamaguchi, T., Nakagawa, M., Motomura, E., Shiroyama, T., Tanii, H., Okada, M.
  • Journal Title: Eur J Pharmacol Volume: 653 Pages: 47-57
  • Peer Reviewed
• [Journal Article] Different actions for acute and chronic administration of mirtazapine on serotonergic transmission associated with raphe nuclei and their innervation cortical regions (2011)
  • Author(s): Yamamura, S., Abe, M., Nakagawa, M., Ochi, S., Ueno, S., Okada, M
  • Journal Title: Neuropharmacology Volume: 60 Pages: 550-560
  • Peer Reviewed
• [Journal Article] Dysfunction of extrasynaptic GABAergic transmission in PRIP-1 KO mice is associated with an epilepsy phenotype (2011)
  • Author(s): Zhu G., Yoshida S., Migita K., Yamada J., Ueno S
  • Journal Title: J Pharmacol Exp Ther Volume: 340(3) Issue: 3 Pages: 520-8
  • DOI: 10.1124/jpet.111.182386
  • URL: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22128345
  • Peer Reviewed
• [Journal Article] Neuroleptic malignant syndrome induced by blonanserin. (2011)
  • Author(s): Ohoyama K, Okada M.
  • Journal Title: J Neuropsychiatry Clin Neurosci. Volume: 23
  • Peer Reviewed
• [Presentation] Mechanisms of absence epilepsy Varidation criteria for genetic animal models of epilepsy (2012)
  • Author(s): Okada M
  • Organizer: 9thAsian & Oceanian Epilepsy Congress
  • Place of Presentation: Manila
  • Year and Date: 2012-03-23
• [Presentation] Epilepsy genes and beyond (2012)
  • Author(s): Okada M
  • Organizer: 9thAsian & Oceanian Epilepsy Congress
  • Place of Presentation: Manila
  • Year and Date: 2012-03-22
• [Presentation] ILAE Lecture: Varidation criteria for genetic animal models of epilepsy (2012)
  • Author(s): Okada M
  • Organizer: 9thAsian & Oceanian Epilepsy Congress
  • Place of Presentation: Manila
  • Year and Date: 2012-03-21
• [Presentation] Epilepsy genes and beyond (2012)
  • Author(s): Okada M
  • Organizer: 9TH ASIAN & OCEANIAN EPILEPSY CONGRESS(招待講演)
  • Place of Presentation: Manila
• [Presentation] 新規てんかん薬物療法のニーズ (2011)
  • Author(s): 岡田元宏
  • Organizer: 第４５回日本てんかん学会(招待講演)
  • Place of Presentation: 新潟
• [Book] 抗てんかん薬の作用機序・薬物動態的特徴. In: 兼子直 (Ed.), てんかん教室改訂第3版 (2012)
  • Author(s): 岡田元宏
  • Publisher: 新興医学出版社
• [Book] 新薬の作用機序. In: 兼子直(Ed.), てんかんの薬物療法 (2012)
  • Author(s): 岡田元宏
  • Publisher: 進行医学出版社
• [Book] 成人てんかんの薬物療法. In: 辻省次 (Ed.), 最新医学別冊 てんかんテキスト (2012)
  • Author(s): 岡田元宏
  • Publisher: 中山書店
• [Book] Novel Treatment of Epilepsy (2011)
  • Author(s): Okada, M. and Kaneko, S.
  • Total Pages: 326
  • Publisher: INTEC
• [Book] 疾患モデルの作製と利用 脳・神経疾患 (2011)
  • Author(s): 岡田元宏
  • Total Pages: 310
  • Publisher: エル・アイ・シー