Study for ultra-fast and highly-sensitive MR spectroscopic imaging using a high-field magnet and a high-performance gradient coil.
| Project/Area Number |
23659584
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INUBUSHI Toshiro 滋賀医科大学, MR医学総合研究センター, 教授 (20213142)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 核磁気共鳴画像(MRI) / 磁気共鳴画像 / MR代謝画像 / エコープラナー法 / 13C-NMR / ＭＲ代謝画像 |
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| Research Abstract |
A high-performance gradient system, with maximal gradient strength of 100 G/cm and inner diameter of 60 mm, was installed to a 7T high-field MR scanner. To realize highly-sensitive 1H-detected 13C spectroscopic imaging of mouse brain using hetero-nuclear multiple-quantum coherence (HMQC), a 1H RF coil system, consisting of a volume coil of 60 mm in diameter for transmission (Tx), a surface coil of 15 mm in diameter for receiving (Rx) and T/R controller, was introduced and a home-built 13C surface coil was combined. A pulse program of EPSI, which utilizes a high-speed echo planar imaging technique, was prepared, but expected increase in time-resolution was not obtained because of the small-sized mouse brain and the wide spectral band width due to the high magnetic field strength of 7T. In chemical shift imaging (CSI) with HMQC, the data acquisitions at 4 corners of k-space with8 x 8 = 64 phase encoding steps were skipped and similar spatial resolution data could be obtained in an approx. 2/3 acquisition time. Using these techniques, sequential changes in metabolite images of 13C-glutamate and glutamine generated from infused 13C-glucose were successfully observed in mouse brain with a time resolution of 20 minutes.
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Report
(3 results)
Research Products
(95 results)
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[Presentation] kayama H, Ninomiya S, Masaki K, Nakanishi K, Mori M, Saito Y, Tsuchikawa S, Endo Y, Morikawa S2013
Author(s)
kayama H, Ninomiya S, Masaki K, Nakanishi K, Mori M, Saito Y, Tsuchikawa S, Endo Y, Morikawa S
Organizer
kayama H, Ninomiya S, Masaki K, Nakanishi K, Mori M, Saito Y, Tsuchikawa S, Endo Y, Morikawa S
Place of Presentation
Venezia, Italy
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[Book] Busse H.(Eds.) Splinger Berlin Heiderberg2012
Author(s)
Hasnine AH, Morikawa S, Naka S, Kurumi Y, Murayama H, Tani T, Tsukamoto T. Simultaneous Endoscopy and MRI Acquisition
Publisher
Simultaneous Endoscopy and MRI Acquisition. In: Interventional Magnetic Resonance Imaging Kahn T
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