Elucidation of the epigenetic gene control as the clinical strategiesfor the patients with radioresistant cervical cancer
| Project/Area Number |
23659597
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | Kansai Medical University |
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Principal Investigator |
HARIMA Yoko 関西医科大学, 医学部, 准教授 (80140276)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Koshi 関西医科大学, 医学部, 講師 (80288802)
UTSUNOMIYA Keita 関西医科大学, 医学部, 講師 (20193914)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 子宮頸癌 / 放射線抵抗性 / 予後予測 / エピジェネティク / 遺伝子制御 / 進行期子宮頸癌 / miRNA / バイオマーカー |
|---|
| Research Abstract |
In this study, we identified miRNA related to outcome of Stage IIIB squamous cell cervical carcinoma after radiotherapy. We compared the expression level of miRNSs in the tumor obtained by punch biopsy before treatment between 8 no evidence of disease [NED] and 6 cancer-caused deaths [CD] group. In the NED group, miR-200a (p=0.013), miR-200b* (p=0.018) and miR-452 (p=0.024) were significantly overexpressed. On the other hand, miR-484 (p=0.038) and hcmv-miR-UL70-3p (p=0.043) were significantlyoverexpressed in the CD group.
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Report
(3 results)
Research Products
(52 results)
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[Journal Article] トロンビンを用いた経動 脈的 Drug Delivery System2011
Author(s)
米虫敦, 谷川昇, 狩谷秀治, 八木理絵, 中谷幸, 鈴木聡史, 池田耕士, 宇都宮啓太, 菅野渉平, 播磨洋子, 澤田敏, 井上理人, 小山田和央, 三宅剛史, 神吉剛, 佐藤遼
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Journal Title
家兎における基礎実験 IVR: Interventional Radiology
Volume: 26
Pages: 236-236
Related Report
Peer Reviewed
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[Journal Article] JROSG(Japanese Radiation Oncology Study Group)の現状-婦人科腫瘍委員会2011
Author(s)
中野隆史, 戸板孝文, 徳丸直郎, 大野達也, 坂田耕一, 加藤真吾, 宇野隆, 清原浩樹, 新部譲, 田中英一, 楮本智子, 兼安祐子, 西村哲夫, 五味弘道, 高橋健夫, 播磨洋子
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Journal Title
癌の臨床
Volume: 56
Pages: 517-524
Related Report
Peer Reviewed
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[Journal Article] トロンビンを用いた経動脈的Drug Delivery System 家兎における基礎実験2011
Author(s)
米虫敦, 谷川昇, 狩谷秀治, 八木理絵, 中谷幸, 鈴木聡史, 池田耕士, 宇都宮啓太, 菅野渉平, 播磨洋子, 澤田敏, 井上理人, 小山田和央, 三宅剛史, 神吉剛, 佐藤遼
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Journal Title
Interventional Radiology
Volume: 26
Pages: 236-236
Related Report
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