| Project/Area Number |
23659629
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
LI Xiaokang 独立行政法人国立成育医療研究センター, 研究所, 室長 (60321890)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 移植 / 再生医療 / 遺伝子 / 細胞・組織 / 移植・再生医療 / 幹細胞 |
|---|
| Research Abstract |
To establish a novel method to generate myeloid-derived suppressor cells(MDSCs) from mouse induced pluripotent stem (iPS). We demonstrated that the iPS cell-derived MDSCs (iPS-MDSCs) possessed the characteristics of MDSCs including the morphology of typical BM-derived MDSC; low expression of the surface molecular, Ia, CD11c, and CD40; capacity of suppress the allogeneic T cell responses. Also we set up a unique mouse GvHD model (B6 to BDF1) for valuation the iPS-MDSCs function by immune cell therapy.
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