| Project/Area Number |
23659637
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MARUYAMA Tetsuro 千葉大学, 医学部附属病院, 医員 (30645586)
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| Research Collaborator |
TAMURA Yutaka 千葉大学, 大学院・医学研究院, 准教授 (50263174)
AKANUMA Naoki 千葉大学, 医学部附属病院, 医員 (70645598)
MARUYAMA Tetsuro 千葉大学, 医学部附属病院, 医員 (30645586)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道癌 / 足場非依存的増殖 / Fra-1 / 浸潤能 / invadepodia / 足場非依存性増殖 / inavadepodia |
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| Research Abstract |
ra-1 is reported one of key molecule inducing anchorage-independent growth that is related to invasion and metastasis in cancer cells. I investigated the role of this molecule in esophageal squamous cell carcinoma (ESCC). I clarified Fra-1 is an important molecule in progression in ESCC. Furthermore, Fascin is also associated with poor prognosis. And Fascin is also related to invasion and metastasis in cancer cells.
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