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Establishment of therapy for individual based on diagnostic imaging by artificial virus

Research Project

Project/Area Number 23659655
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

TANAKA Masao  九州大学, 医学研究院, 教授 (30163570)

Co-Investigator(Kenkyū-buntansha) EGAMI Takuya  九州大学, 医学研究院, 共同研究員 (40507787)
TAKAHATA Shunichi  九州大学, 大学病院, 助教 (50437779)
ONIMARU Manabu  九州大学, 医学研究院, 共同研究員 (80529876)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / drug delivery system / 人工ウイルス
Research Abstract

We revealed HGF/c-MET pathway reduced the efficacy of virus therapy through cancer-stroma interaction. To selectively detect the specific high-grade cancer cell population, we selected CXCR4 and c-MET and created selective MRI imaging agent.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (9 results)

All 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma2012

    • Author(s)
      Tsutsumi K, Sato N, Tanabe R, Mizumoto K, Morimatsu K, Kayashima T, Fujita H, Ohuchida K, Otsuka T, Takahata S, Nakamura M, Tanaka M
    • Journal Title

      Annals of Surgical oncology

      Volume: 19(3) Pages: 491-499

    • Related Report
      2012 Final Research Report
  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
    • Journal Title

      Anticancer Research

      Volume: 31(4) Pages: 1279-1288

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway2011

    • Author(s)
      Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
    • Journal Title

      Cancer science

      Volume: 102(2) Pages: 484-491

    • NAID

      10029290639

    • Related Report
      2012 Final Research Report
  • [Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer2011

    • Author(s)
      Sakai H, Ouchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
    • Journal Title

      Annals of Surgical oncology

      Volume: 18(7) Pages: 2057-2065

    • Related Report
      2012 Final Research Report
  • [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway.2011

    • Author(s)
      Yasui T et al.
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 484-491

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells.2011

    • Author(s)
      Yasui T et al.
    • Journal Title

      Anticancer Research

      Volume: 31 Pages: 1279-87

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Inhibition of p600 expression suppresses bothi nvasiveness and anoikis resistance of gastric cancer.2011

    • Author(s)
      Sakai H et al.
    • Journal Title

      Annals of Surgical Oncolgy

      Volume: 18 Pages: 2057-2065

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma.2011

    • Author(s)
      Tsutsumi K et al.
    • Journal Title

      Annals of Surgical Oncolgy

      Volume: In press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] claudin-4発現は膵癌の予後予測因子として有用である2011

    • Author(s)
      堤宏介、佐藤典宏、大内田研宙、大塚隆生、高畑俊一、中村雅史、水元一博、田中雅夫
    • Organizer
      第49回日本癌治療学会学術総会
    • Related Report
      2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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