Development of implantable three-dimensional device with the induction of olfactory ensheathing cells with high axonal regeneration effect
| Project/Area Number |
23659685
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMINE Toshiki 大阪大学, 脳神経外科, 教授 (00201046)
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| Co-Investigator(Renkei-kenkyūsha) |
IWATSUKI Koichi 大阪大学, 脳神経外科, 講師 (80346204)
UMEGAKI Masao 大阪大学, 脳神経外科, 特任研究員 (30448063)
ISHIHARA Masahiro 大阪大学, 脳神経外科, 特任研究員 (00533803)
OHNISHI Yuichiro 大阪大学, 脳神経外科, 医員 (00533811)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脊髄損傷 / 嗅粘膜移植法 / 新生再生 / olfactory epithelium / lamina propria / NGF / VEGF / 抗PSA-NCAM抗体 / 抗L1CAM抗体 / 嗅神経鞘細胞 / 細胞外マトリックス / 軸索伸長 / 細胞移動 |
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| Research Abstract |
Including neural stem cells, olfactory ensheathing cells olfactory ensheathing cell and (OEC), and in the spinal cord injury treatment, olfactory mucosa is one of the leading cell source. There is variation in the reports of neurite outgrowth-promoting effect of OEC isolated from the olfactory mucosa in many studies. To the cause, not only OEC isolated, there is interaction with other cells that are included in the olfactory mucosa. As a result of separating the olfactory epithelium olfactory epithelium that make up the olfactory mucosa (OE), olfactory mucosa lamina propria lamina propria the (LP), we examined the difference in the interaction with the axon, PSA-which is expressed in the OEC of LP in that NCAM is involved in direct interaction with the axon has been shown.
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Report
(4 results)
Research Products
(5 results)
