| Project/Area Number |
23659688
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA Junya 愛媛大学, プロテオ医学研究センター, 教授 (70217040)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Hajime 愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki 愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana 愛媛大学, 大学院・医学系研究科, 助教 (00581034)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Takanori 愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki 愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳梗塞 / マイクログリア / 脳損傷 / アストロサイト / 細胞移植 / マクロファージ / 骨髄 / BINCs |
|---|
| Research Abstract |
To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.
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