Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome
| Project/Area Number |
23659688
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA Junya 愛媛大学, プロテオ医学研究センター, 教授 (70217040)
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| Co-Investigator(Kenkyū-buntansha) |
YANO Hajime 愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki 愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana 愛媛大学, 大学院・医学系研究科, 助教 (00581034)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNISHI Takanori 愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki 愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳梗塞 / マイクログリア / 脳損傷 / アストロサイト / 細胞移植 / マクロファージ / 骨髄 / BINCs |
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| Research Abstract |
To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013
Author(s)
Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
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Journal Title
J Neurosci Res
Volume: 91
Pages: 681-693
Related Report
Peer Reviewed
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[Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012
Author(s)
Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J
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Journal Title
J Cell Biochem
Volume: 113
Pages: 508-517
Related Report
Peer Reviewed
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[Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages2011
Author(s)
NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J
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Journal Title
Brain Res
Volume: 1420
Pages: 114-124
Related Report
Peer Reviewed
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