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Determination of cell type(s) that should be transplanted into lesion core of the brain for better outcome

Research Project

Project/Area Number 23659688
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionEhime University

Principal Investigator

TANAKA Junya  愛媛大学, プロテオ医学研究センター, 教授 (70217040)

Co-Investigator(Kenkyū-buntansha) YANO Hajime  愛媛大学, 大学院・医学系研究科, 准教授 (00284414)
TAKAHASHI Hisaaki  愛媛大学, 医学部附属病院, 講師 (20363228)
SUGIMOTO Kana  愛媛大学, 大学院・医学系研究科, 助教 (00581034)
Co-Investigator(Renkei-kenkyūsha) OHNISHI Takanori  愛媛大学, 大学院・医学系研究科, 教授 (70233210)
KUMON Yoshiaki  愛媛大学, 大学院・医学系研究科, 准教授 (80127894)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳梗塞 / マイクログリア / 脳損傷 / アストロサイト / 細胞移植 / マクロファージ / 骨髄 / BINCs
Research Abstract

To determine cell type(s) that should be transplanted into the lesion core of ischemic and traumatic brain injuries with an aim to ameliorate the outcomes, several kinds of cultured neural cells including microglial cells, astrocytes, and brain macrophages isolated from ischemic lesion core of rat brains. Consequently,it was found that most of transplanted cells were eliminated by phagocytic macrophages in spite of the isotransplantation. Only BINCs were transplantable into the ischemic core, and their transplantation may be appeared therapeutically effective.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 2011 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (10 results) (of which Invited: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013

    • Author(s)
      Nari Tei, Junya Tanaka, Kana Sugimoto, Tasuku Nishihara, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Shirabe Matsumoto, Shiro Ohue, Hideaki Watanabe, Yoshiaki Kumon, Takanori Ohnishi
    • Journal Title

      J Neurosci Res

      Volume: 91 Pages: 681-693

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of MCP-1 and fractalkine on endothelial cells and astrocytes may contribute to the invasion and migration of brain macrophages in ischemic rat brain lesions2013

    • Author(s)
      Nari Tei
    • Journal Title

      J Neurosci Res

      Volume: 91 Issue: 5 Pages: 681693-681693

    • DOI

      10.1002/jnr.23202

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children2012

    • Author(s)
      Hitomi Hino, Hisaaki Takahashi, Yuka Suzuki, Junya Tanaka, Eiichi Ishii, Mitsumasa Fukuda
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 8 Pages: e42920-e42920

    • DOI

      10.1371/journal.pone.0042920

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zonisamide up-regulated them RNAs encoding astrocytic anti-oxidative and neurotrophic factors.2012

    • Author(s)
      Choudhury ME, Sugimoto K, Kubo M, Iwaki H, Tsujii T, Kyaw WT, Nishikawa N, Nagai M, Tanaka J, Nomoto M
    • Journal Title

      Eur J Pharmacol

      Volume: 689 Pages: 72-80

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes2012

    • Author(s)
      Mayorca-Guiliani AE, Yano H, Nakashiro KI, Hamakawa H, Tanaka J
    • Journal Title

      Oral Oncology

      Volume: 48 Pages: 663-670

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012

    • Author(s)
      Kobayashi K, Takahashi H, Inoue A, Harada H, Toshimori S, Kobayashi Y, Goto K, Sugimoto K, Yano H, Ohnishi T, Tanaka J
    • Journal Title

      J Cell Biochem

      Volume: 113 Pages: 508-517

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zonisamide up-regulated them RNAs encoding astrocytic anti-oxidative and neurotrophic factors2012

    • Author(s)
      Choudhury ME
    • Journal Title

      Eur J Pharmacol

      Volume: 689 Issue: 1-3 Pages: 7280-7280

    • DOI

      10.1016/j.ejphar.2012.05.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Premetastatic vasculogenesis in oral squamous cell carcinoma xenograft-draining lymph nodes2012

    • Author(s)
      Mayorca-Guiliani AE
    • Journal Title

      Oral Oncology

      Volume: 48 Issue: 8 Pages: 663670-663670

    • DOI

      10.1016/j.oraloncology.2012.02.007

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oct-3/4 promotes migration and invasion of glioblastoma cells2012

    • Author(s)
      Kobayashi K
    • Journal Title

      J Cell Biochem

      Volume: 113 Issue: 2 Pages: 508517-508517

    • DOI

      10.1002/jcb.23374

    • Related Report
      2012 Annual Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages2011

    • Author(s)
      NakataT, Kawachi K, Nagashima M, Yasugi T, Izutani H, Ryugo M, Okamura T, Shikata F, Imagawa H, Yano H, Takahashi H, Tanaka J
    • Journal Title

      Brain Res

      Volume: 1420 Pages: 114-124

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cytokine mixture of GM‐CSF and IL‐3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6‐OHDA)‐induced Parkinsonism of rats2011

    • Author(s)
      Choudhury ME, Sugimoto K, Kubo M, Nagai M, Nomoto M, Takahashi H, Yano H, Tanaka J
    • Journal Title

      Brain Behav

      Volume: 1 Pages: 26-43

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats2011

    • Author(s)
      Nishihara, Michihisa Ochi, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
    • Journal Title

      Exp Neurol

      Volume: 229 Pages: 507-516

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats2011

    • Author(s)
      Nishihara, T., et al
    • Journal Title

      Experimental neurology

      Volume: 229 Issue: 2 Pages: 507-516

    • DOI

      10.1016/j.expneurol.2011.04.006

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transient ischemia-induced paresis and complete paraplegia displayed distinct reactions of microglia and macrophages2011

    • Author(s)
      Nakata, T., et al
    • Journal Title

      Brain research

      Volume: 1420 Pages: 114-124

    • DOI

      10.1016/j.brainres.2011.08.074

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A cytokine mixture of GM-CSF and IL-3 that induces a neuroprotective phenotype of microglia leading to amelioration of (6-OHDA)-induced Parkinsonism of rats2011

    • Author(s)
      Choudhry, E., et al
    • Journal Title

      Brain and Behavior

      Volume: 1 Issue: 1 Pages: 26-43

    • DOI

      10.1002/brb3.11

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Agents modulating neuroprotective and neurotoxic functions of microglia and their application to the pathologic brains2013

    • Author(s)
      Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-182013

    • Author(s)
      Ayano Mise, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano, Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors2013

    • Author(s)
      Yudai Ohara, Kana Sugimoto, Ryutaro Nishioka, Hisaaki Takahashi, Hajime Yano、Nari Tei, Yoshiaki Kumon, Takanori Ohnishi, Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Final Research Report
  • [Presentation] Agents modulating neuroprotective and neurotoxic functions of microglia and their application to the pathologic brains2013

    • Author(s)
      Junya Tanaka
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Response of glial cells in and around ischemic lesion of rats that were subjected to transient middle cerebral artery occlusion: the involvement of IL-182013

    • Author(s)
      Ayano Mise
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Invasion of monocytes/macrophages into ischemic lesion of rat brain: involvement of chemokines and their receptors2013

    • Author(s)
      Yudai Ohara
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] A cytokine mixture containing GM-CSF and IL-3 targeting microglia ameliorates neurological deficits of Parkinson's disease model rats2012

    • Author(s)
      Junya Tanaka, Mohammed E. Choudhury, Kana Sugimoto, Hisaaki Takahashi, Hajime Yano
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      大分県由布市
    • Related Report
      2012 Final Research Report
  • [Presentation] 脳梗塞巣に集積するマクロファージの役割とその治療的利用2012

    • Author(s)
      田中潤也、杉本香奈、西原佑、高橋寿明、矢野元
    • Organizer
      第22回日本病態生理学会
    • Place of Presentation
      大分県由布市
    • Related Report
      2012 Final Research Report
  • [Presentation] Microglial cells expressing NG2 chondroitin sulfate proteoglycan in ischemic brain lesions of rats2012

    • Author(s)
      杉本香奈 他
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      長野県松本市
    • Related Report
      2011 Research-status Report
  • [Presentation] 神経細胞傷害に対するグリア細胞の反応:ラット6-OHDA負荷パーキンソン病モデルを用いた検討2011

    • Author(s)
      田中潤也 他
    • Organizer
      第21回日本病態生理学会大会
    • Place of Presentation
      東京都板橋区
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.m.ehime-u.ac.jp/school/kisogp/contents/laboratories

    • Related Report
      2012 Final Research Report
  • [Patent(Industrial Property Rights)] 免疫細胞の活性化抑制剤およびその用途2012

    • Inventor(s)
      田中潤也
    • Industrial Property Rights Holder
      国立大学法人愛媛大学
    • Industrial Property Number
      2012-173405
    • Filing Date
      2012-08-03
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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