| Project/Area Number |
23659689
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Oita University of Nursing and Health Sciences (2012-2013)
International University of Health and Welfare (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
天野 託 国際医療福祉大学, 薬学部, 教授 (10294547)
中谷 善彦 国際医療福祉大学, 薬学部, 助教 (40582169)
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| Co-Investigator(Renkei-kenkyūsha) |
中谷 善彦 国際医療福祉大学, 薬学部, 助教 (40582169)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 悪性グリオーマ / 血管内皮前駆細胞 / TRAIL / avidin-biotin system / biotin-avidin / biotin-avidin system |
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| Research Abstract |
Due to their unique property to cross the blood-brain barier and to migrate to pathological lesions, endothelial progenitor cell (EPC) is expected as a new therapeutic tool for malignant glioma. EPCs were genetically modified by using tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in the first aproach. On the other hand, the surface of EPC was modified by using avidin-niotin system and TRAIL protein. Modified EPCs were proved to be effective to induce the apoptosis of malignant glioma cells.
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