Effect of abnormalities in asymmetric cell divisions of neural stem cells on brain tumor initiation
| Project/Area Number |
23659690
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kochi University |
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Principal Investigator |
SHIMIZU Keiji 高知大学, 教育研究部医療学系, 教授 (70116044)
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| Co-Investigator(Kenkyū-buntansha) |
YAWATA Toshio 高知大学, 教育研究部・医療学系, 助教 (40380323)
HIGASHI Yoichiro 高知大学, 教育研究部・医療学系, 助教 (80380062)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳腫瘍 / エピジェネティクス / 分化 / 悪性脳腫瘍 / 幹細胞 / 非対称分裂 |
|---|
| Research Abstract |
A method for distinguishing a stem cell from a differentiated cell using stemness gene’s promoter was developed to examine the abnormal asymmetrical cell division in malignant glioma cell cultures and tissues. By flow cytometric analysis using stem and precursor cell markers, it was revealed that glioma stem and precursor cells over-expressed MDR1 (multiple drug resistance 1) and exhibited low susceptibility to DNA damage by anti-cancer drugs.
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Report
(3 results)
Research Products
(41 results)
