Project/Area Number |
23659706
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Orthopaedic surgery
|
Research Institution | The University of Tokyo |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HARA Nobuhiro 東京大学, 医学部附属病院, 助教 (00422296)
ONO Takashi 東京大学, 医学部附属病院, 特任助教 (00506248)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 脊椎脊髄病学 / 椎間板 / 変形性脊椎症 / 椎間板変性 |
Research Abstract |
We established a new mouse model of spondylosis. In this model, we identified that annulus fibrosus cells exhibit hypertrophic change morphologically with expression of type 10 collagen. Also we succeeded in identifying a candidate gene which can be a marker of annulus fibrosus of intervertebral disc.
|