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Inhibition of bacterial adhesion on the surface of titanium implant

Research Project

Project/Area Number 23659711
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionThe University of Tokyo

Principal Investigator

TANAKA Takeyuki  東京大学, 医学部・附属病院, 助教 (00583121)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kozo  東京大学, 医学部附属病院, 教授 (60126133)
ISHIHARA Kazuhiko  東京大学, 大学院・工学系研究科, 教授 (90193341)
MIURA Toshiki  東京大学, 医学部附属病院, 講師 (20376479)
ITO Hideya  東京大学, 医学部附属病院, 助教 (30436464)
KONNO Tomohiro  東京大学, 大学院・工学系研究科, 特任准教授 (80371706)
Project Period (FY) 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords医療・福祉 / 細菌 / ナノ材料
Research Abstract

To inhibit the infection around the implant of artificial joint, we have developed a new technology, surface grafting of a biocompatible polymer for titanium alloy. In addition, we have revealed that biocompatible polymer grafted surface prevented the bacterial adhesion in the experimental infection model. From these results of the study, we believe that this new technology will prevent the infection around the implant of artificial joint.

Report

(2 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • Research Products

    (30 results)

All 2012 2011

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (25 results)

  • [Journal Article] Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials2012

    • Author(s)
      Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, Takatori Y, Ishihara K
    • Journal Title

      Biomaterials

      Volume: 33 Pages: 4451-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biomimetic hydration lubrication with various polyelectrolyte layers on cross-linked polyethylene orthopedic bearing materials2012

    • Author(s)
      Kyomoto M, Moro T, Saiga K, Hashimoto M, Ito H, Kawaguchi H, Takatori Y, Ishihara K
    • Journal Title

      Biomaterials

      Volume: (in press) Issue: 18 Pages: 4451-9

    • DOI

      10.1016/j.biomaterials.2012.03.028

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel polymer biomaterials and interfaces inspired from cell membrane functions2011

    • Author(s)
      Ishihara K, Goto Y, Matsuno R, Inoue Y, Konno T
    • Journal Title

      Biochim Biophys Acta-General

      Volume: 1810(3) Pages: 268-75

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adsorption force of proteins against hydrophilic polymer brush surfaces2011

    • Author(s)
      Inoue Y, Nakanishi T, Ishihara K
    • Journal Title

      React Funct Polym

      Volume: 71(3) Pages: 350-5

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adhesion force of proteins against hydrophilic polymer brush surfaces2011

    • Author(s)
      Inoue Y, Nakanishi T, Ishihara K
    • Journal Title

      React Fund Polym

      Volume: 71(3) Issue: 3 Pages: 350-5

    • DOI

      10.1016/j.reactfunctpolym.2010.11.017

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Direct evaluation of interaction force between proteins and polymer brush surfaces with well-characterized hydration state2012

    • Author(s)
      Inoue Y, Inoue K, Ishihara K
    • Organizer
      5th International Symposium of Nanomedicine
    • Place of Presentation
      Nagoya
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of protein adsorption at polymer brush surfaces based on the water structure surrounding the surface2012

    • Author(s)
      Inoue Y, Ishihara K
    • Organizer
      American Chemical Aciety, Spring 2013 National Meeting & Exposition
    • Place of Presentation
      San Diego, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本発の高性能ポリマーバイオマテリアルMPCポリマーの創発と応用2011

    • Author(s)
      石原一彦
    • Organizer
      医療機器フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2011-10-03
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質吸着過程のナノ解析による生体親和型ポリマー表面の設計2011

    • Author(s)
      井上祐貴,中西智亮,石原一彦
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質吸着に与えるポリマーブラシ表面の水和状態の効果2011

    • Author(s)
      井上和臣,井上祐貴,石原一彦
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] ナノバイオマテリアル・インテグレーションと未来医学2011

    • Author(s)
      石原一彦
    • Organizer
      ナノ学会第9回大会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] ブロックコポリマーの自己組織化相分離構造による細胞接着性の制御2011

    • Author(s)
      柴山崇, Seo Ji-Hun,石原一彦,高井まどか
    • Organizer
      第23回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] MPCポリマーの表面処理による人工関節金属表面の細菌付着抑制効果2011

    • Author(s)
      茂呂徹,高取吉雄,中村耕三,石原一彦,京本政之,安藤嘉基,宮本比呂志,伊藤英也,角田俊治,田中健之,大嶋浩文,雑賀健一,川口浩
    • Organizer
      第34回日本骨・感染症学会
    • Place of Presentation
      淡路島
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 未来を拓くナノ医療とは?-新しい医療原則の確立と価値の創出2011

    • Author(s)
      石原一彦,山岡哲二
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質吸着を支配するポリマーブラシ表面近傍の水和状態2011

    • Author(s)
      井上祐貴,井上和臣,石原一彦
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] 生体親和性ポリマーブラシ表面でのタンパク質との相互作用力のナノ解析2011

    • Author(s)
      坂田翔,井上祐貴,石原一彦
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Related Report
      2011 Final Research Report
  • [Presentation] 人工関節金属インプラント表面のMPC処理による細菌付着抑制効果の検討2011

    • Author(s)
      茂呂徹,高取吉雄,石原一彦,京本政之,安藤嘉基,宮本比呂志,伊藤英也,角田俊治,田中健之,大嶋浩文,中村耕三,川口浩
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 低侵襲医療に役立つ生体親和型ポリマーバイオマテリアル2011

    • Author(s)
      石原一彦
    • Organizer
      東海ライブ研究会
    • Place of Presentation
      豊橋
    • Related Report
      2011 Final Research Report
  • [Presentation] MPCポリマーの基礎と応用2011

    • Author(s)
      石原一彦
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] タンパク質吸着に与えるポリマーブラシ表面の水和状態の影響2011

    • Author(s)
      井上和臣,井上祐貴,石原一彦
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] High oxidation-and wear-resistance of PMPC-grafted polyethylene arisen by extra plasma irradiation2011

    • Author(s)
      Kyomoto M, Moro T, Saiga K, Takatori Y, Ishihara K
    • Organizer
      2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Inhibition of inflammatory responses on phospholipid polymer-coated nanoparticles2011

    • Author(s)
      Ishihara K, Goto Y, Matsuno R, Inoue Y, Konno T, Takai M
    • Organizer
      2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Cytocompatible polymer surface with photocleavable groups for regulating the single cell attachment/detachment2011

    • Author(s)
      Byambaa B, Konno T, Ishihara K
    • Organizer
      2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Elucidation of protein adsorption behavior based on molecular dynamics around polymer brush surface2011

    • Author(s)
      Inoue Y, Nakanishi T, Ishihara K
    • Organizer
      2011 Annual Meeting & Exposition of the Society for Biomaterials(SFB)
    • Place of Presentation
      Orlando, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Surface modification withphospholipid polymers for long-term implantable medical devices2011

    • Author(s)
      Ishihara K, Kyomoto M, Moro T, Inoue Y
    • Organizer
      THERMEC' 2011
    • Place of Presentation
      Quebec, Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] Importance of dynamics of water molecules on protein adsorption at polymer brush surfaces2011

    • Author(s)
      Inoue K, Inoue Y, Ishihara K
    • Organizer
      The 3rd Asian Biomaterials Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Highly biocompatible surface for implatable artificial organ2011

    • Author(s)
      Ishihara K
    • Organizer
      The 3rd Asian Biomaterials Congress
    • Place of Presentation
      Busan, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Biomimetic surface modification on artificial hip joint for elongation of implantation life2011

    • Author(s)
      Ishihara K, Kyomoto M, Moro T, Takatori Y
    • Organizer
      European Society for Artificial Organs(ESAO)
    • Place of Presentation
      Porto, Portugal
    • Related Report
      2011 Final Research Report
  • [Presentation] Surface modification with phospholipid polymers for long-term implantable medical devices2011

    • Author(s)
      Ishihara K, Kyomoto M, Moro T, Inoue Y
    • Organizer
      THERMEC'2011
    • Place of Presentation
      Quebec, Canada
    • Related Report
      2011 Annual Research Report
  • [Presentation] Biomimetic surface modification on artificial hip joint for elongation of implantation life2011

    • Author(s)
      Ishihara K, Kyomoto M, Moro T, Takatori Y
    • Organizer
      European Society for Artificial Organs (ESAO)
    • Place of Presentation
      Porto, Portugal
    • Related Report
      2011 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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