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The effect of advanced glycation end products to meniscal degeneration of osteoarthritic knees

Research Project

Project/Area Number 23659716
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

HIRAIWA Hideki  名古屋大学, 医学部附属病院, 病院助教 (70566976)

Co-Investigator(Kenkyū-buntansha) SAKAI Tadahiro  名古屋大学, 大学院・医学系研究科, 講師 (60378198)
HAMADA Takashi  名古屋大学, 大学院・医学系研究科, 助教 (90566978)
YAMAMOTO Ryuichiro  名古屋大学, 大学院・医学系研究科, 医員 (80586743)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords関節病学 / 軟骨代謝 / 加齢 / 変形性膝関節症 / 後期糖化最終生成物
Research Abstract

To obtain a novel knowledge about the progression of osteoarthritic knee, we investigated the function of advanced glycation endproducts (AGE) and the receptor of AGE (RAGE) in the process of osteoarthritisusing the cartilage and the meniscus from osteoarthritic knee. The catabolic effects ofmeniscus by AGE were regulated through RAGE pathways, and were suppressed by hyaluronan which is used for treatment of osteoarthritic knee. Moreover, S100 protein, that is one of the ligand of RAGE and secreted by damaged tissues of osteoarthritic knee, regulated the catabolic effects of cartilage via p38 MAPK and NF-kappaB pathways.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2012 2011

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (20 results)

  • [Journal Article] Role of S100A12 in the pathogenesis of osteoarthritis2012

    • Author(s)
      Motoshige Nakashima
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 422 Issue: 3 Pages: 508-514

    • DOI

      10.1016/j.bbrc.2012.05.036

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory effect of advanced glycation end products on human meniseal cells from osteoarthritic knees2011

    • Author(s)
      Hiraiwa H, Sakai T, Mitsuyama H, Hamada T, Yamamoto R, Omachi T, Ohno Y, Nakashima M, Ishiguro N
    • Journal Title

      Inflamm Res

      Volume: 60(11) Issue: 11 Pages: 1039-48

    • DOI

      10.1007/s00011-011-0365-y

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Geranylgeranylacetone suppresses hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytes2011

    • Author(s)
      Yoda M, Sakai T, Mitsuyama H, Hiraiwa H, Ishiguro N
    • Journal Title

      J Orthop Sci

      Volume: 16(6) Issue: 6 Pages: 791-8

    • DOI

      10.1007/s00776-011-0138-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] OA半月板におけるHIF-2αの高発現2012

    • Author(s)
      石塚真哉, 酒井忠博, 平岩秀樹, 濱田恭ら
    • Organizer
      第40回日本関節病学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-11-08
    • Related Report
      2012 Final Research Report
  • [Presentation] S100A12タンパクによる変形性関節症の進行における影響2012

    • Author(s)
      中島基成, 酒井忠博, 平岩秀樹, 濱田恭ら
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 変形性関節症(OA)半月板細胞におけるhypoxiainducible factor-2α(HIF-2α)の高発現と軟骨内骨化関連遺伝子の制御2012

    • Author(s)
      石塚真哉, 酒井忠博, 平岩秀樹, 濱田恭ら
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-10-26
    • Related Report
      2012 Final Research Report
  • [Presentation] The effect of S100A12 in the pathogenesis of osteoarthritis2012

    • Author(s)
      Nakashima M, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, et al
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2012-02-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased expression of Hypoxia-inducible factor-2alfa in osteoarthritic meniscus cells2012

    • Author(s)
      Ishizuka S, Sakai T, Hiraiwa H, Hamada T, Ishiguro N, et al
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco, California, USA
    • Year and Date
      2012-02-04
    • Related Report
      2012 Final Research Report
  • [Presentation] Increased expression of Hypoxia-inducible factor-2α in osteoarthritic meniscus cells2012

    • Author(s)
      Ishizuka,S; Sakai, T; Hiraiwa, H; Hamada, T;Nakashima, M; Oda T; Takamatsu A; YamashitaS; Ishiguro, N
    • Organizer
      第40回日本関節病学会
    • Place of Presentation
      鹿児島市民文化ホール、鹿児島サンロイヤルホテル(鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] S100A12タンパクによる変形性関節症の進行における影響2012

    • Author(s)
      中島基成、酒井忠博、平岩秀樹、濱田恭、石塚真哉、小田智之、高松晃、山下暁士、石黒直樹
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 変形性関節症(OA)半月板細胞におけるhypoxiainducible factor-2α(HIF-2α)の高発現と軟骨内骨化関連遺伝子の制御2012

    • Author(s)
      石塚真哉、酒井忠博、平岩秀樹、濱田恭、中島基成、小田智之、高松晃、山下暁士、石黒直樹
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市熱田区)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Ectopic Ossification in the Regenerated Tissue at the Tendon Defect Site2012

    • Author(s)
      takaaki omachi
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] Increased expression of Hypoxia-inducible factor-2alfa in osteoarthritic cells2012

    • Author(s)
      shinya ishizuka
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] the effectof S100A12 in the pathogenesisof osteoarthriris2012

    • Author(s)
      motoshige nakashima
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] Chondrogenic potential of redifferentiated human osteoarthritic chondrocytes and their phenotypic alterations during de- and re-differentiation process in vitro2012

    • Author(s)
      yohei ohno
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] MicroRNA-23b and 27b regulate both Hypoxia-inducible factor-2α and endochondral ossification related gene expressions in osteoarthritic chondrocytes2012

    • Author(s)
      shinya ishizuka
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] MicroRNA-125b Regulates the Expression of Aggrecanase-1 (ADAMTS4) in Human2012

    • Author(s)
      tetsuya matsukawa
    • Organizer
      Orthopaedic Research Society
    • Place of Presentation
      San Francisco
    • Related Report
      2011 Research-status Report
  • [Presentation] 変形性関節症の発生機序におけるS100A12タンパクの影響2012

    • Author(s)
      中島基成
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋(ウィルあいち)
    • Related Report
      2011 Research-status Report
  • [Presentation] 変形性関節症(OA)半月板細胞におけるHypoxia-inducible facyor-2α(HIF-2α)の発現増加2012

    • Author(s)
      石塚真哉
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋(ウィルあいち)
    • Related Report
      2011 Research-status Report
  • [Presentation] microRNA-23b、27bはOAの軟骨細胞においてhypoxia-inducible factor-2α(HIF2-α)及び軟骨内骨化関連遺伝子の発現を制御する2012

    • Author(s)
      石塚真哉
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋(ウィルあいち)
    • Related Report
      2011 Research-status Report
  • [Presentation] 人OA細胞におけるMicroRNA-125bによるAggrecanase-1(ADAMTS4)の発現制御2012

    • Author(s)
      松川哲也
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋(ウィルあいち)
    • Related Report
      2011 Research-status Report
  • [Presentation] 膝蓋靭帯欠損部再生組織の長期経過観察2011

    • Author(s)
      大間知孝顕
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋(ベイシア文化ホール(群馬県民会館)、 前橋商工会議所)
    • Related Report
      2011 Research-status Report
  • [Presentation] 単層培養ヒトOA軟骨細胞の再分化能と表現型変化2011

    • Author(s)
      大野洋平
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋(ベイシア文化ホール(群馬県民会館)、 前橋商工会議所)
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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