Involvement of Toll-like receptors in the Actions of Opioids
Project/Area Number |
23659742
|
Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
Allocation Type | Multi-year Fund |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | オピオイド / モルヒネ / 耐性 / マイクログリア / ノックアウトマウス / toll-like receptor |
Research Abstract |
To examine the hypothesis that the toll-like receptor 4 (TLR4) is involved in the morphine-induced activation of microglia, we analyzed morphine tolerance in TLR4 knockout mice and C3H/HeJ mice possessing mutated TLR4. It was shown that morphine tolerance was induced in both knockout and mutant mice similarly as wild-type mice, and suggested that TLR4 is not involved in morphine-induced activation of microglia. Our results suggest that morphine tolerance is mediated by microglia activated through the mechanism other than TLR4.
|
Report
(3 results)
Research Products
(4 results)