Establishment of cancer stem cells and the therapeutic strategy in malignant Mullerian tumors
| Project/Area Number |
23659787
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
MAKOTO EMOTO 国際医療福祉大学, 保健医療学部, 教授 (80258540)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 癌幹細胞 / ミューラー管腫瘍 / 子宮癌肉腫 / CD133 / PAX2 / 血管新生 / VEGF / ミューラー管悪性腫瘍 / 間葉系幹細胞 / FU-MMT-1 / SOX2 / 子宮肉腫 / Angiopoietin / 超音波 / がん幹細胞 / ミューラー管 / 婦人科腫瘍 / Oct4 / Wnt4 / 婦人科癌 / 4-Oct |
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| Outline of Final Research Achievements |
The biological characteristics of malignant Mullerian tumors (Uterine carcinosarcomas) are still unclear. We identified the cancer stem cells in this tumor by using FU-MMT-1 cells, which was established by our own from human uterine carcinosarcoma (Emoto M. Cancer 1992). These cancer stem cells in FU-MMT-1 significantly expressed OCT4, NANOG, SOX2, C-MYC, BMI-1 as well as the Mullerian gene, PAX2 and WNT-4. The CD133 positive FU-MMT-1 cells also possessed high angiogenic activity (high expression of VEGF-A), thus, the anti-angiogenic therapy might be expected as a new therapeutic strategy for these tumors.
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Report
(5 results)
Research Products
(12 results)
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[Journal Article] AG73-modified Bubble liposomes for targeted ultrasound imaging of tumor neovasculature2013
Author(s)
Negishi Y, Hamano M, Tsunoda Y, Oda Y, Batsuren C, Takahashi Y, Omata D, Suzuki R, Maruyama K, Nomizu M, Emoto M, Aramaki Y
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Journal Title
Biomaterials
Volume: 34
Pages: 501-507
Related Report
Peer Reviewed
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