Development of animal model with esophageal atresia

Research Project

Project/Area Number	23659824
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Pediatric surgery
Research Institution	Jichi Medical University
Principal Investigator	ONO Shigeru 自治医科大学, 医学部, 准教授 (00315962)
Co-Investigator(Kenkyū-buntansha)	SASAKI Yasunari 京都府立医科大学, 医学研究科, その他 (30405253)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	先天性食道閉鎖症 / 動物モデル / 食道閉鎖症 / レチノイン酸 / 食道閉鎖症モデル
Research Abstract	The aim of this study is the development of animal model with esophageal atresia to develop a new treatment procedure including surgical technique. We tried to develop rabbit model with esophageal atresia using oral administration of Retinoic acid. Variety of doses of all-trans Retinoic acid were administrated, however no anomaly including esophageal atresia were observed excepting some melting fetus.