Establishment of a skin-humanized mouse model of keloid

• Project/Area Number: 23659835
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Jichi Medical University
• Principal Investigator: MIYAZAKI Kunio 自治医科大学, 医学部, 助教 (20528591)
• Co-Investigator(Renkei-kenkyūsha): SUNAGA Ataru 自治医科大学, 医学部, 助教 (00406117)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 創傷治癒学 / ケロイド / 動物モデル

Research Abstract

In this study, we developed a skin-humanized mouse model of keloid by using spontaneous cell-sorting technique. Engraftment of the mixed cell slurries containing keloid -derived keratinocytes and fibroblasts in a double-chamber on the back of NOD