| Project/Area Number |
23659866
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ECHIGO Seishi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70005114)
WASHIO Jumpei 東北大学, 大学院・歯学研究科, 助教 (20400260)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌組織 / メタボローム解析 / 糖代謝 / アミノ酸代謝 |
|---|
| Research Abstract |
Metabolome analyses of oral squamous cancer (OSC) were performed by CE-TOFMS, targeting metabolites of Embden-Meyerhof-Parnas pathway (EMPP),pentose-phosphate pathway, TCA cycle and metabolic pathways for amino acids. Method for metabolome analyses of OSC was established. The results suggest that the enhancement of EMPP (Warburg effect) occurred in OSC, as previously reported for other cancers, and that amino acids such as glutamine were utilized as an additional energy source for OSC.
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