Metabolomic approach to metabolic biology of cancer cells
Project/Area Number |
23659866
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Tohoku University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
ECHIGO Seishi 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (70005114)
WASHIO Jumpei 東北大学, 大学院・歯学研究科, 助教 (20400260)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 癌組織 / メタボローム解析 / 糖代謝 / アミノ酸代謝 |
Research Abstract |
Metabolome analyses of oral squamous cancer (OSC) were performed by CE-TOFMS, targeting metabolites of Embden-Meyerhof-Parnas pathway (EMPP),pentose-phosphate pathway, TCA cycle and metabolic pathways for amino acids. Method for metabolome analyses of OSC was established. The results suggest that the enhancement of EMPP (Warburg effect) occurred in OSC, as previously reported for other cancers, and that amino acids such as glutamine were utilized as an additional energy source for OSC.
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Report
(3 results)
Research Products
(96 results)
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[Journal Article] Rapid quantification of bacteria in infected root canals using fluorescence filter : A pilot study on its clinical application to the evaluation of the outcomes of endodontic treatment2012
Author(s)
Sato T, Yamaki K, Ishida N, Shoji M, Sato E, Abiko Y, Hashimoto K, Takeuchi Y, Matsuyama J, Shimauchi H, Takahashi N
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Journal Title
Int J Dent
Volume: Volume 2012(Article ID 172935)
Pages: 4-4
DOI
Related Report
Peer Reviewed
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[Journal Article] Rapid quantification of bacteria in infected root canals using fluorescence filter: A pilot study on its clinical application to the evaluation of the outcomes of endodontic treatment.2012
Author(s)
Sato T, Yamaki K, Ishida N, Shoji M, Sato E, Abiko Y, Hashimoto K, Takeuchi Y, Matsuyama J, Shimauchi H, Takahashi N
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Journal Title
Int J Dent
Volume: 2012
Pages: 2012-2012
Related Report
Peer Reviewed
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[Journal Article] Rapid quantification of bacteria in infected root canals using fluorescence filter - A pilot study on its clinical application to the evaluation of the outcomes of endodontic treatment -2012
Author(s)
Sato T, Yamaki K, Ishida N, Shoji M, Sato E, Abiko Y, Hashimoto K, Takeuchi Y, Matsuyama J, Shimauchi H, Takahashi N
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Journal Title
Related Report
Peer Reviewed
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[Presentation] バイオマテリアル-パラサイト・インターフェイスへの挑戦-バイオマテリアルの生物学的劣化の理解へ-2012
Author(s)
高橋信博,真柳弦,中條和子,鷲尾純平,佐藤拓一,竹内裕尚,佐久間陽子,松尾洋,末永華子,鈴木治,佐々木啓一
Organizer
九州大学応用力学研究所平成23年度共同利用研究集会「力学適応能、自己組織化能を有するバイオマテリアル-生体インターフェイスの創製」(招待講演)
Place of Presentation
福岡
Year and Date
2012-03-02
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