| Project/Area Number |
23659894
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
WATANABE Makoto 東北大学, 大学院・歯学研究科, 客員教授 (80091768)
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| Co-Investigator(Kenkyū-buntansha) |
OGASAWARA Kouetsu 東北大学, 加齢医学研究所, 教授 (30323603)
TSUBOI Akito 東北大学, 東北メディカル・メガバンク 機構, 教授 (00241646)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 超高純度鉄 / 臨床応用 / in vivo 安全性試験 / 加工技術 / 代替材料 / 安全性試験 / 革新技術 |
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| Research Abstract |
Dental metal has increased the patient's QOL as a repair material. However, safer alternative materials are desired, because there is a possibility that several oral disease may be caused by dental metal. The "ultra-high purity iron (UHP-Fe)" that is the next-generation material unparalleled in the world has been generated in the Institute for Materials Research at Tohoku University. We also developed the novel safety test for evaluating biomaterials using experimental animal model. In this study, our purpose is to examine whether UHP-Fe is valuable for safer biomaterials in the clinical application using the safety test in vivo. We injected the wire of UHP-Fe into the mice subcutaneously, Five days later we obtained the surrounding tissue embedded in the metal wire. To investigate the elution of metal ions in the in vivo, we were dissolved the surrounding tissue and the solution was analyzed by mass spectrum analysis metal ions quantitative analysis technique (ICP-MS method). In addition, the removed wires were detected the corrosion of metal surfaces by scanning electron microscopy (SEM method). There is almost no corrosion of the surface ultra-high purity iron and inflammation of the subcutaneous tissue was not observed. Therefore, ultra-high purity iron is a safe biological material, suggesting that it will become a new medical biomaterial in the future.
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