Development of a technic to generate somatic stem cells using a newly reprogramming method.
| Project/Area Number |
23659899
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
KUBOKI Takuo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)
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| Co-Investigator(Kenkyū-buntansha) |
SONOYAMA Wataru 岡山大学, 大学病院, 講師 (40325121)
UCHIBE Kenta 岡山大学, 岡山大学病院, 医員 (20584618)
ONO Mitsuaki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (60613156)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リプログラミング / 歯髄細胞 / 組織幹細胞 |
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| Research Abstract |
We performed a screening for factors involved in the regulation of maintenance of stemness in dental pulp cells (DPCs). As a result, we found that TNF-αwas involved in maintenance of stemness, and increased the number of cells positive for stem cell surface markers CD146 and SSEA4. Moreover, we also identified some microRNAs that regulate stemness, proliferation and differentiation of DPCs.
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Report
(3 results)
Research Products
(5 results)
