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Development of a technic to generate somatic stem cells using a newly reprogramming method.

Research Project

Project/Area Number 23659899
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Prosthetic dentistry
Research InstitutionOkayama University

Principal Investigator

KUBOKI Takuo  岡山大学, 大学院・医歯薬学総合研究科, 教授 (00225195)

Co-Investigator(Kenkyū-buntansha) SONOYAMA Wataru  岡山大学, 大学病院, 講師 (40325121)
UCHIBE Kenta  岡山大学, 岡山大学病院, 医員 (20584618)
ONO Mitsuaki  岡山大学, 大学院・医歯薬学総合研究科, 助教 (60613156)
Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsリプログラミング / 歯髄細胞 / 組織幹細胞
Research Abstract

We performed a screening for factors involved in the regulation of maintenance of stemness in dental pulp cells (DPCs). As a result, we found that TNF-αwas involved in maintenance of stemness, and increased the number of cells positive for stem cell surface markers CD146 and SSEA4. Moreover, we also identified some microRNAs that regulate stemness, proliferation and differentiation of DPCs.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (5 results)

All 2012 2011

All Presentation (4 results) Patent(Industrial Property Rights) (1 results)

  • [Presentation] A comparative analysis of the effect of rhTNF-αtreatment on the stem cell phenotype of cells derived from dental pulp, periodontal ligament and bone marrow.2012

    • Author(s)
      Pham Thanh Hai, T.Kuboki, et al
    • Organizer
      The Asean Plus and Tokushima Joint International Conference
    • Place of Presentation
      Yogyakarta, Indonesia.
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of transient TNF-αtreatment on the stem cell phenotype of human periodontal ligament cells and bone marrow stromal cells2012

    • Author(s)
      Pham Thanh Hai, T.Kuboki, et al
    • Organizer
      Japanese Association of Regenerative Dentistry 10th Annual Meeting
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 生物学的配慮と臨床事実に基づいた口腔リハビリテーション医学を構築するためにー臨床疫学,バイオメカニクス,そしてバイオロジーへー2012

    • Author(s)
      窪木拓男
    • Organizer
      新潟大学歯学部大学院セミナー(招待講演)
    • Place of Presentation
      新潟,日本
    • Related Report
      2011 Research-status Report
  • [Presentation] 抜歯窩肉芽組織由来間葉系幹細胞の同定2011

    • Author(s)
      中島 隆, 大野充昭, 園山 亘, 笈田育尚, Hara Emilio Satoshi, 窪木拓男
    • Organizer
      第29回 日本骨代謝学会学術集会
    • Place of Presentation
      大阪, 日本
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 新規間葉系幹細胞2011

    • Inventor(s)
      窪木拓男,大野充昭,園山 亘,中島 隆,笈田育尚
    • Industrial Property Rights Holder
      窪木拓男,大野充昭,園山 亘,中島 隆,笈田育尚
    • Industrial Property Number
      2011-111873
    • Filing Date
      2011
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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